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TGFβRI-IN-1

Catalog No. T13137   CAS 1950628-94-0

TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively ).

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TGFβRI-IN-1 Chemical Structure
TGFβRI-IN-1, CAS 1950628-94-0
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,520.00
50 mg 6-8 weeks $ 1,980.00
100 mg 6-8 weeks $ 2,500.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively ).
Targets&IC50 TGFβRI:2 nM
In vitro various cellular responses regulated by Transforming Growth Factor-β signaling such as cell proliferation, differentiation, cell migration and cell death. TGF-β has at least three isoforms TGF-β1, TGF-β2 and TGF-β3. TGF-β1 is two well-conserved single membrane serine/threonine kinase type I (ALK5). ALK5 inhibitos can be used for treating fibrotic disease, tumor, inflammatory disease, and autoimmune disease.
Molecular Weight 362.4
Formula C20H14D3N5O2
CAS No. 1950628-94-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Yong Zhang, et al. Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents. ACS Med. Chem. Lett.20189111117-1122.

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Halofuginone Kartogenin Skullcapflavone II GW-6604 Trimethylamine N-oxide Monocrotaline TGFβRI-IN-3 SB-431542

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Keywords

TGFβRI-IN-1 1950628-94-0 Stem Cells TGF-beta/Smad TGFβRIIN1 TGFβRI IN 1 TGFbetaRI-IN-1 TGFbRI-IN-1 inhibitor inhibit

 

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