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PF-06952229

Catalog No. T12433 CAS 1801333-55-0

Synonyms: PF06952229

PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PF-06952229, CAS 1801333-55-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 116.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 793.00
50 mg	In stock	$ 1,130.00
100 mg	In stock	$ 1,520.00
500 mg	In stock	$ 2,970.00
1 mL * 10 mM (in DMSO)	In stock	$ 318.00

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Purity: 99.45%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.
Targets&IC50	transforming growth factor-beta receptor 1:
In vivo	In MCF-7 ER+ HER2-xenograft breast cancer tumor model, PF-06952229 (30 mg/kg; gavage) combines with Palbociclib results in an improved inhibition of pSMAD2 and a significant increase in survival[1].

Synonyms	PF06952229
Molecular Weight	458.91
Formula	C23H24ClFN4O3
CAS No.	1801333-55-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 40 mg/mL (87.2 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Flavia Mercer Pernasetti, et al. Combinations of tgfb inhibitors and cdk inhibitors for the treatment of breast cancer. Patent WO2020058820A1.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Clinical Compound Library Anti-Prostate Cancer Compound Library Anti-Cancer Drug Library Bioactive Compounds Library Max Anti-Cancer Active Compound Library Anti-Ovarian Cancer Compound Library Anti-Colorectal Cancer Compound Library Bioactive Compound Library Inhibitor Library

Related Products

Related compounds with same targets

ALK2-IN-2 CJJ300 AXL-IN-13 BMT-124110 Formate Chromenone 1 SIS3 free base Dalbergioidin TGFβRI-IN-1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PF-06952229 1801333-55-0 Stem Cells TGF-beta/Smad PF06952229 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.