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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12893 | SGLT inhibitor-1 | SGLT | |
SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively). | |||
T9590 | T-1095 | SGLT , transporter | |
T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2). | |||
T2385 | Ipragliflozin | ASP1941 | SGLT |
Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2. | |||
T15656 | KGA-2727 | SGLT | |
KGA-2727 is a potent and selective SGLT1 inhibitor, with Kis of 97.4 nM and 43.5 nM for human and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA... | |||
T1766 | Empagliflozin | BI 10773 | SGLT |
Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6. Empagliflozin is used for the treatment of type 2 diabetes. | |||
T2389 | Dapagliflozin | BMS-512148 | SGLT , HIF |
Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. | |||
T38843 | Enavogliflozin | DWP-16001 | SGLT |
Enavogliflozin (DWP-16001) is an orally available small molecule and sodium glucose transporter 2 inhibitor. | |||
T2S0731 | Trilobatin | P-Phlorizin | Amylase |
Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory respon... | |||
T3547 | Sotagliflozin | LX-4211,LP-802034 | SGLT |
Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity. | |||
T15244 | Ertugliflozin L-pyroglutamic acid | PF-04971729 L-pyroglutamic acid | Others , SGLT |
Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a selective and orally active hSGLT2 inhibitor with an IC50 of 0.877 nM. Ertugliflozin L-pyroglutamic acid can be used for studies about the treatmen... | |||
T2922 | Phlorizin | Floridzin,NSC 2833,Phloridzin | ATPase , SGLT |
Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) . | |||
T4999 | Ertugliflozin | MK-8835,PF-04971729 | SGLT |
PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2). | |||
T5016 | Tofogliflozin (hydrate) | Tofogliflozin hydrate,CSG-452 hydrate | SGLT , Reactive Oxygen Species , ROS |
Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2). | |||
T2924 | Phloretin | Dihydronaringenin,NSC 407292,RJC 02792 | SGLT , transporter , Endogenous Metabolite |
Phloretin (NSC-407292) is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leav... | |||
T1782 | Canagliflozin | JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754 | SGLT |
Canagliflozin (JNJ 28431754AAA), a sodium-glucose transporter 2( SGLT2) and P-Glycoprotein inhibitor, is used in type 2 diabetes. | |||
T39966 | SGLT1/2-IN-2 | SGLT1/2-IN-2 | |
SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM). | |||
T4460 | Dapagliflozin ((2S)-1,2-propanediol, hydrate) | BMS-512148 (2S)-1,2-propanediol, hydrate,Dapagliflozin propanediol monohydrate | SGLT |
Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). It is in development for the tre... | |||
T15752 | Licogliflozin | LIK066 | SGLT |
Licogliflozin (LIK066) is an inhibitor of sodium-glucose cotransporter (SGLT1 and SGLT2). | |||
T16083 | Mizagliflozin | GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base | SGLT |
Mizagliflozin (GSK-1614235 free base) is a sodium-glucose transporter inhibitor( Ki of 27 nM for human SGLT1). Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic drug that ca... | |||
T62830 | SGLT1/2-IN-1 | ||
SGLT1/2-IN-1 is a dual SGLT1/SGLT2 inhibitor. |