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Search Result

Search Results for " secret "

Targets

Beta-Secretase Gamma-secretase Gamma-secretase

37

Compounds

11

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T62263 γ-Secretase modulator 13 Gamma-secretase
γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease and tumors.
T9713 δ-secretase inhibitor 11 Beta Amyloid , Caspase
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
TP1039 Secretin (33-59), rat Secretin (rat) Glucagon Receptor
Secretin (33-59), rat (Secretin (rat)) is a classical hormone in the gastrointestinal system and a neuropeptide.
T11358 Gamma-secretase modulator 1 N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine Gamma-secretase
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.
T3521 γ-Secretase-IN-1 Compound E Beta Amyloid , Gamma-secretase
γ-Secretase-IN-1 is a potent γ-secretase inhibitor that displays partial antiproliferative activity on T-47D cells and inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage.
TP1597L Secretoneurin, rat acetate Secretoneurin, rat acetate(149146-12-3 Free base) Others
Secretoneurin, rat acetate is a 33-amino acid polypeptide generated by proteolytic processing of secretogranin II (SgII). Secretoneurin, rat acetate induces dopamine release in the rat striatum in vivo and in vitro, and ...
T64258 Gamma-secretase modulator 5
gamma-secretase modulator 5 (compound 22d) is a gamma-secretase modulator (GSMs) that crosses the blood-brain barrier and exhibits an inhibitory effect on the production of the aggregated amyloid β peptide Aβ42 (IC50: 60...
T11359 Gamma-secretase modulator 2 Others
Gamma-secretase modulator 2 is a potent, selective compound for the treatment of Alzheimer's disease, specifically designed to modulate γ-secretase activity. This modulation selectively attenuates the production of Aβ(1-...
TP1136 Secretin (28-54), human Human secretin
Secretin (28-54), human, is a 27-amino acid residue peptide with a C-terminal amidation, acting on human secretin receptors.
TP1610 Secretin, canine
Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Canine secretin can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers b...
T75863 Secretin (33-59), rat TFA
Secretin (33-59), rat (TFA), a 27-amino acid peptide, targets the secretin receptor to increase the release of bicarbonate, enzymes, and potassium (K+) from the pancreas [1] [2].
TP1135 Secretin (28-54), human TFA Human secretin TFA
Secretin (28-54), human TFA is a 27-amino acid peptide that works on the human Secretin receptor.
TP1047 Secretin, porcine TFA (17034-34-3 free base) Porcine secretin TFA,Secretin, porcine TFA
Secretin, porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid.Secretin porcine stimulates panc...
T11360 Gamma-secretase modulator 3 Others
gamma-secretase modulator 3 is a gamma-secretase modulator.
T39089 Acid secretion-IN-1
Acid secretion-IN-1, a polycyclic compound, is synthesized for its application as an IDO inhibitor in synthetic experiments.
T40260 β-Secretase Inhibitor II
β-Secretase Inhibitor II is a tripeptide aldehyde compound that acts as an inhibitor of β-Secretase. It exhibits a simple structure and has an inhibitory potency of IC50 = 700 nM against total Aβ and IC50 = 2.5 μM specif...
T40315 γ-Secretase modulator 10
γ-Secretase modulator 10 is a novel γ-secretase modulator.
T65428 Secretin,porcine
Secretin,porcine is a useful organic compound for research related to life sciences and the catalog number is T65428.
T34600 Secretin (1-6) Secretin,N-terminal hexapeptide
Secretin (1-6) is the N-terminal part of secretin. It can produce vitro glucose-dependent insulin release induced by secretin.
T11361 γ-Secretase modulator 4 Others
γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.
T11362 Gamma-Secretase Modulators γ-Secretase Modulators,Amyloid-β production inhibitor Others
gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.
TP1597 Secretoneurin, rat
Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII).
T81182 Secretin (swine)
Secretin (swine), a neuroendocrine hormone first identified as secreted by S cells in the duodenal mucosa, is a 27-amino acid peptide targeting secretin receptors. Present in all mature enteroendocrine cell subsets, it i...
T63638 γ-Secretase modulator 11 hydrochloride
γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM). γ-Secretase modulator 11 hydrochloride significantly reduces brain Aβ42 levels and rescues the cognitive deficits ...
T63216 γ-Secretase modulator 11
5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and brain exposure, was able to cause a significant reduction in b...
T10064 LH secretion antagonist 1 Others
LH secretion antagonist 1 is an antagonist of luteinizing hormone secretion with analgesic activity.
T62455 β-Secretase Inhibitor III
β-Secretase Inhibitor III is a highly selective inhibitor of BACE1 with a Ki value of 0.13 nM.
T75973 Secretin, porcine TFA
Secretin, Porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide that targets pancreatic acinar and ductal epithelial cells, inducing the secretion of bicarbonate-rich fluid [1].
TP1038 Secretin (33-59), rat TFA (121028-49-7 free base) Secretin (33-59), rat TFA,Secretin (rat) (TFA)
Secretin (33-59), rat (TFA) is a 27-aa peptide, which acts on secretin receptor, and enhances the secretion of bicarbonate, enzymes, and K+ from the pancreas[1][2].
TP1048 Secretin, porcine Porcine secretin acetate
Secretin, porcine (Porcine secretin acetate) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid. Secretin porcine stimulates pan...
T11358L Gamma-secretase modulator 1 hydrochloride gamma-secretase modulator 1 hydrochloride (1172637-87-4 free base) Others
gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].
T61881 γ-Secretase modulator 12
γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM. It is specifically designed for Alzheimer's disease research. Notably, γ-Secretas...
T13434 β-Secretase Inhibitor IV Others
β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).
T39251 β-Secretase Inhibitor I
β-Secretase Inhibitor I is a highly potent inhibitor of the β-secretase enzyme. This compound exhibits exceptional inhibitory activity while also demonstrating a significant reduction in cardiovascular and liver toxicity...
T64685 Secretin xAcetate
Secretin xAcetate is a useful organic compound for research related to life sciences and the catalog number is T64685.
T3161 β-Secretase inhibitor-STA Beta-Secretase
BACE-IN-1 is amyloid precursor protein beta-secretase inhibitor
TP1144L Corticotropin-releasing factor (human) acetate Corticotropin-releasing factor (human) acetate (86784-80-7 Free base) CRFR
Corticotropin-releasing factor (human) acetate stimulates to synthesize and secret adrenocorticotropin in the anterior pituitary.

Compounds

γ-Secretase modulator 13
T62263
Synonym:
Target: Gamma-secretase
δ-secretase inhibitor 11
T9713
Synonym:
Target: Beta Amyloid, Caspase
Secretin (33-59), rat
TP1039
Synonym: Secretin (rat)
Target: Glucagon Receptor
gamma-secretase modulator 1
T11358
Synonym: N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine
Target: Gamma-secretase
γ-Secretase-IN-1
T3521
Synonym: Compound E
Target: Beta Amyloid, Gamma-secretase
Secretoneurin, rat acetate
TP1597L
Synonym: Secretoneurin, rat acetate(149146-12-3 Free base)
Target: Others
gamma-secretase modulator 5
T64258
Synonym:
Target:
gamma-secretase modulator 2
T11359
Synonym:
Target: Others
Secretin (28-54), human
TP1136
Synonym: Human secretin
Target:
Secretin, canine
TP1610
Synonym:
Target:
Secretin (33-59), rat TFA
T75863
Synonym:
Target:
Secretin (28-54), human TFA
TP1135
Synonym: Human secretin TFA
Target:
Secretin, porcine TFA (17034-34-3 free base)
TP1047
Synonym: Porcine secretin TFA,Secretin, porcine TFA
Target:
gamma-secretase modulator 3
T11360
Synonym:
Target: Others
Acid secretion-IN-1
T39089
Synonym:
Target:
β-Secretase Inhibitor II
T40260
Synonym:
Target:
γ-Secretase modulator 10
T40315
Synonym:
Target:
Secretin,porcine
T65428
Synonym:
Target:
Secretin (1-6)
T34600
Synonym: Secretin,N-terminal hexapeptide
Target:
γ-Secretase modulator 4
T11361
Synonym:
Target: Others
gamma-Secretase Modulators
T11362
Synonym: γ-Secretase Modulators,Amyloid-β production inhibitor
Target: Others
Secretoneurin, rat
TP1597
Synonym:
Target:
Secretin (swine)
T81182
Synonym:
Target:
γ-Secretase modulator 11 hydrochloride
T63638
Synonym:
Target:
γ-Secretase modulator 11
T63216
Synonym:
Target:
LH secretion antagonist 1
T10064
Synonym:
Target: Others
β-Secretase Inhibitor III
T62455
Synonym:
Target:
Secretin, porcine TFA
T75973
Synonym:
Target:
Secretin (33-59), rat TFA (121028-49-7 free base)
TP1038
Synonym: Secretin (33-59), rat TFA,Secretin (rat) (TFA)
Target:
Secretin, porcine
TP1048
Synonym: Porcine secretin acetate
Target:
gamma-secretase modulator 1 hydrochloride
T11358L
Synonym: gamma-secretase modulator 1 hydrochloride (1172637-87-4 free base)
Target: Others
γ-Secretase modulator 12
T61881
Synonym:
Target:
β-Secretase Inhibitor IV
T13434
Synonym:
Target: Others
β-Secretase Inhibitor I
T39251
Synonym:
Target:
Secretin xAcetate
T64685
Synonym:
Target:
β-Secretase inhibitor-STA
T3161
Synonym:
Target: Beta-Secretase
Corticotropin-releasing factor (human) acetate
TP1144L
Synonym: Corticotropin-releasing factor (human) acetate (86784-80-7 Free base)
Target: CRFR

Recombinant Proteins

Species：
Human (6)
Burkholderia thailandensis (1)
Cynomolgus (1)
HEV-1 (1)
Mouse (1)
Rat (1)
Expression System：
HEK293 Cells (5)
E. coli (4)
Baculovirus Insect Cells (1)
P. pastoris (Yeast) (1)
Tag：
C-His (5)
N-6xHis-GST (2)
N-10xHis (1)
N-10xHis, C-Myc (1)
N-6xHis (1)
N-His (1)
Cat No. Product Name Species Expression System
TMPY-01875 SCGN Protein, Human, Recombinant (His) Human E. coli
Secretagogin, also known as SCGN, is a secreted protein that is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high level...
TMPH-00813 Hepatitis E virus genotype 1 (HEV-1) Secreted protein ORF2 (His) HEV-1 Baculovirus Insect Cells
Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.; Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked...
TMPK-01122 SG3/Secretogranin 3 Protein, Human, Recombinant (aa 20-468, His) Human HEK293 Cells
Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 was recently discovered as an angiogenic factor, expanding its functional role to extrinsic regu...
TMPH-02068 Secretogranin-1 Protein, Human, Recombinant (GST & His) Human E. coli
Secretogranin-1 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
TMPY-03994 SG3/Secretogranin 3 Protein, Human, Recombinant (His) Human HEK293 Cells
SG3/Secretogranin 3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.4 kDa and the accession number is AAH14539.1.
TMPH-00319 Type III secretion system needle Protein, Burkholderia thailandensis, Recombinant (His) Burkholderia thailandensis P. pastoris (Yeast)
Type III secretion system needle Protein, Burkholderia thailandensis, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 11.9 kDa and the accession number is Q2T727.
TMPK-00673 SG3/Secretogranin 3 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 was recently discovered as an angiogenic factor, expanding its functional role to extrinsic regu...
TMPH-03368 SG3/Secretogranin 3 Protein, Rat, Recombinant (His & Myc) Rat E. coli
Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes...
TMPY-03968 Secretogranin II Protein, Human, Recombinant (His) Human HEK293 Cells
Kit ligand, also known as Hematopoietic growth factor KL, Mast cell growth factor, Steel factor, Stem cell factor, c-Kit ligand, Kitlg and KITL, is a single-pass type I membrane protein that belongs to the SCF family. KI...
TMPY-04675 SG3/Secretogranin 3, Mouse, Recombinant (His) Mouse HEK293 Cells
SG3/Secretogranin 3, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.4 kDa and the accession number is P47867-1.
TMPH-02069 Secretogranin-2 Protein, Human, Recombinant (GST & His) Human E. coli
Secretogranin-2 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
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