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δ-secretase inhibitor 11

Catalog No. T9713 CAS 842964-18-5

δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.

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δ-secretase inhibitor 11 Chemical Structure

δ-secretase inhibitor 11, CAS 842964-18-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 43.00
25 mg	In stock	$ 97.00
50 mg	In stock	$ 167.00
100 mg	In stock	$ 249.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99.4%

Biological Description

Chemical Properties

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Description	δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
In vitro	The inhibitory effect of δ-secretase inhibitor 11 on AEP activity in vitro was tested and the dose-response relationship revealed that the δ-secretase inhibitor 11 had an IC50 value of 0.15 ± 0.09 μM [1].
In vivo	It was found that oral administration of δ-secretase inhibitor 11 (10 mg/kg) significantly suppressed brain AEP activity compared to the vehicle treatment. The concentrations of Aβ1–40 and Aβ1–42 in brain lysates of SAMP8 mice were significantly reduced due to AEP inhibition by δ-secretase inhibitor 11. [1]

Molecular Weight	220.23
Formula	C10H12N4O2
CAS No.	842964-18-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.2 mg/mL (10 mM)

References and Literature

1. Ju Wang, et al. Pharmacological inhibition of asparaginyl endopeptidase by δ-secretase inhibitor 11 mitigates Alzheimer’s disease-related pathologies in a senescence-accelerated mouse model. Translational Neurodegeneration volume 10, Article number: 12 (2021).

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Pyroptosis Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Related compounds with same targets

PE859 Isorosmanol γ-Secretase-IN-1 BSBM7 FPS-ZM1 ALZ-801 Tramiprosate 8-Deoxygartanin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

δ-secretase inhibitor 11 842964-18-5 Apoptosis Neuroscience Proteases/Proteasome Beta Amyloid Caspase δ-Secretase inhibitor 11 CNS diseases Alzheimer's disease δ secretase inhibitor 11 β-amyloid peptide oxygen-glucose deprivation amyloid precursor protein Abeta asparagine endopeptidase Inhibitor APP AEP Amyloid-β delta-secretase inhibitor 11 Pala cells δsecretase inhibitor 11 inhibit inhibitor

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