rapamycin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1537	Rapamycin	Sirolimus,AY 22989,NSC-2260804	Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal
	Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
T38963	Seco Rapamycin	Secorapamycin A
	Seco Rapamycin, also known as Secorapamycin A, is a ring-opened derivative derived from Rapamycin. It has been observed that Seco-rapamycin does not impact the function of mTOR.
T36314	Wortmannin-Rapamycin Conjugate
	Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin...
T12691	Rapamycin-d3	AY-22989-d3,Sirolimus-d3	Others
	Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific inhibitor of mTOR(IC50 of 0.1 nM in HEK293 cells).		Others
T10158	42-(2-Tetrazolyl)rapamycin		Others
	42-(2-Tetrazolyl)rapamycin is a prodrug compound of a rapamycin analog.		Others
T19558	Seco Rapamycin sodium salt	Secorapamycin A monosodium	Others
	Seco Rapamycin sodium salt is a ring-opened product of Rapamycin.		Others
T25882	7-O-Demethyl rapamycin	CJ 12263,CJ12263,7-O-Demethyl Rapammune,Novolimus (80%),7-O-Demethyl Cypher,Novolimus,CJ-12263
	Novolimus is a macrocyclic lactone with anti-proliferative properties. It has similar efficacy to currently available agents but requires a lower dose.
T74014	Seco Rapamycin ethyl ester
	Seco Rapamycin ethyl ester, an open-ring metabolite of the Rapamycin derivative, reportedly does not impact mTOR function [1].
T14033	3BDO		Apoptosis , mTOR , Autophagy
	3BDO is an activator of mTOR. It can also inhibit autophagy..		Apoptosis , mTOR , Autophagy
T40351	MHY-1685		mTOR
	MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.		mTOR
T6030	XL388		P450 , PI3K , mTOR
	XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.		P450 , PI3K , mTOR
T6045	Torin 1		DNA-PK , PI3K , mTOR , Autophagy
	Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.		DNA-PK , PI3K , mTOR , Autophagy
T1859	AZD-8055		Apoptosis , mTOR , Autophagy
	AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.		Apoptosis , mTOR , Autophagy
T5472	PQR620		mTOR
	PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.		mTOR
T2475	KU-0063794		mTOR
	KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.		mTOR
T3514	CZ415		mTOR
	CZ415 is a potent and highly selective mTOR inhibitor.		mTOR
T12270	NV-5138		mTOR
	NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.		mTOR
T12123	MTOR inhibitor-3		mTOR
	mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.		mTOR
T5338	MTOR inhibitor-1		mTOR , Autophagy
	C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.		mTOR , Autophagy
T6100	Torin 2		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
	Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 2...		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy