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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36243 | PROTAC RIPK degrader-6 | ||
PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linker to a cereblon binder[1]. | |||
T16755 | RIPK-IN-4 | TNF | |
RIPK-IN-4 is an effective and selective inhibitor of RIPK2. It also has excellent oral bioavailability (IC50: 3 nM). | |||
T13846 | PROTAC RIPK degrader-2 | Others | |
PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation. | |||
T12731 | RIPK1-IN-7 | RIP kinase | |
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. | |||
T12730 | RIPK1-IN-4 | RIP kinase | |
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase). | |||
T3537 | GSK583 | RIP kinase | |
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM). | |||
T7795 | RIPA-56 | RIP kinase | |
RIPA-56 is an inhibitor of RIP1 | |||
T7151 | GSK2982772 | RIP kinase | |
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively. | |||
T6815 | HS-1371 | RIP kinase | |
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM. | |||
T9305 | Necroptosis-IN-1 | RIP kinase | |
Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1. | |||
T9702 | Eclitasertib | RIP kinase | |
Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ). | |||
T15437 | GSK3145095 | RIP kinase | |
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic. | |||
T5054 | GSK963 | GSK963 (Racemate) | RIP kinase |
GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM). | |||
T11501 | GSK840 | GSK'840 | RIP kinase |
GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC50: 0.3 nM). | |||
T11492 | GSK2983559 free acid | Others , RIP kinase | |
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking many proinflammatory cytokine responses in human inflammato... | |||
T6852 | GSK481 | GSK'481 | RIP kinase |
GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death. | |||
T7397 | GSK547 | GSK'547 | RIP kinase |
GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer. | |||
T12493 | PK68 | Others , RIP kinase | |
PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of inflammatory disorders and cancer metastasis. | |||
T1847 | Necrostatin-1 | Nec-1,Necrostatin 1 | Indoleamine 2,3-Dioxygenase (IDO) , Ferroptosis , Autophagy , RIP kinase |
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO. | |||
T4074 | GSK-872 | GSK872,GSK'872,GSK2399872A | RIP kinase |
GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM). |