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Catalog No. T7795   CAS 1956370-21-0

RIPA-56 is an inhibitor of RIP1

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RIPA-56, CAS 1956370-21-0
Pack Size Availability Price/USD Quantity
5 mg In stock $ 32.00
10 mg In stock $ 48.00
25 mg In stock $ 86.00
50 mg In stock $ 138.00
100 mg In stock $ 225.00
200 mg In stock $ 333.00
500 mg In stock $ 559.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 100%
Purity: 98.45%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description RIPA-56 is an inhibitor of RIP1
Targets&IC50 RIP1:13 nM
In vivo In the SIRS mice disease model, RIPA-56?efficiently reduced tumor necrosis factor alpha (TNFα)-induced mortality and multi-organ damage.?Compared to known RIP1 inhibitors, RIPA-56?is potent in both human and murine cells, is much more stable in vivo, and is efficacious in animal model?studies.
Molecular Weight 221.3
Formula C13H19NO2
CAS No. 1956370-21-0


Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (451.88 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ren Y , Su Y , Sun L , et al. Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome[J]. Journal of Medicinal Chemistry, 2017, 60(3):972-986.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Bioactive Compounds Library Max NF-κB Signaling Compound Library Cytokine Inhibitor Library Anti-Liver Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library Antidepressant Compound Library NO PAINS Compound Library Anti-Ovarian Cancer Compound Library

Related Products

Related compounds with same targets
RIPK1-IN-4 RIPK1-IN-9 HTH-01-091 RIP2 Kinase Inhibitor 3 GSK2593074A OD36 hydrochloride WEHI-345 GSK872 HCl(1346546-69-7 free base)

Dose Conversion

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Molarity Calculator
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Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box


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Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box


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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.


Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.


RIPA-56 1956370-21-0 Apoptosis NF-Κb RIP kinase inhibit Receptor-interacting protein kinases RIPK Inhibitor RIPA 56 RIPA56 inhibitor