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Eclitasertib

Catalog No. T9702 CAS 2125450-76-0

Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Eclitasertib, CAS 2125450-76-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 157.00
5 mg	In stock	$ 317.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 1,037.00
50 mg	In stock	$ 1,667.00
100 mg	In stock	$ 2,657.00
1 mL * 10 mM (in DMSO)	In stock	$ 367.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).
Targets&IC50	RIPK1:<1 µΜ

Molecular Weight	378.392
Formula	C19H18N6O3
CAS No.	2125450-76-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (330.36 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Anthony A. ESTRADA, et al. Compounds, compositions and methods. WO2017136727A2.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Clinical Compound Library Anti-Ovarian Cancer Compound Library Anti-Cancer Compound Library Anti-Prostate Cancer Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Inhibitor Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets

Eclitasertib RIPA-56 GSK547 HS-1371 GSK-872 Necrostatin-5 GSK3145095 RIPK1-IN-4

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Eclitasertib 2125450-76-0 Apoptosis NF-Κb RIP kinase SAR-443122 RIPK Receptor-interacting protein kinases SAR443122 DNL 758 DNL758 Inhibitor DNL-758 inhibit SAR 443122 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.