protac — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12551	PROTAC BRD4 ligand-1		Epigenetic Reader Domain , Ligands for Target Protein for PROTAC
	PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET.
T5835	PROTAC ERRα ligand 2		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM)		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T15191	PROTAC ERRα ligand 1		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	PROTAC ERRα ligand 1 is an α (ERRα) antagonist of estrogen-related receptor (IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively).		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T5437	Gefitinib-based PROTAC 3		EGFR
	Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectivel...		EGFR
T13722	Homo-PROTAC pVHL30 degrader 1		Others , Ligand for E3 Ligase
	Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.		Others , Ligand for E3 Ligase
T13848	SMARCA-BD ligand 1 for Protac		Epigenetic Reader Domain
	SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2		Epigenetic Reader Domain
T13721	Homo-PROTAC cereblon degrader 1		Others , Ligand for E3 Ligase
	Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.		Others , Ligand for E3 Ligase
T13890	SMARCA-BD ligand 1 for Protac dihydrochloride		Epigenetic Reader Domain
	SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.		Epigenetic Reader Domain
T74186	PROTAC-O4I2		Apoptosis , PROTACs
	PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM. PROTAC-O4I2 induced apoptosis in K562 WT cells.		Apoptosis , PROTACs
T34168	PROTAC-I	PROTAC I
	PROTAC-I targets steroid hormone receptors for ubiquitination and degradation.
T8745	PROTAC BRAF-V600E degrader-1	Compound 23	Raf
	PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.		Raf
T39901	PROTAC IRAK4 degrader-4	PROTAC IRAK4 degrader-4
	PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
T40073	PROTAC BRD4 Degrader-10	PROTAC BRD4 Degrader-10
	PROTAC BRD4 Degrader-10, also known as compound 8b, is a dual ligand-based PROTAC that combines ligands for von Hippel-Lindau and BRD4. To degrade the BRD4 protein in PC3 prostate cancer cells, PROTAC BRD4 Degrader-10 ca...
T40334	PROTAC IRAK3 degrade-1	PROTAC IRAK3 degrade-1
	PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 ( IC 50 = 5 nM).
T39997	PROTAC CDK9 ligand-1	PROTAC CDK9 ligand-1
	PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.
T37329	PROTAC IDO1 Degrader-1	PROTAC IDO1 Degrader-1
	PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the...
T40075	PROTAC BRD4 Degrader-13	PROTAC BRD4 Degrader-13
	PROTAC BRD4 Degrader-13 (compound 9d) is a bioactive compound that functions as a proteolysis targeting chimera (PROTAC), linking ligands for von Hippel-Lindau and BRD4 proteins. In the context of PC3 prostate cancer cel...
T39996	PROTAC CDK9 degrader-4	PROTAC CDK9 degrader-4
	PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9...
T39920	PROTAC IRAK4 degrader-3	PROTAC IRAK4 degrader-3
	PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.
T36242	PROTAC BRD4 Degrader-5	PROTAC BRD4 Degrader-5
	PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].