0-4℃ for short term (days to weeks), or -20℃ for long term (months).
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | 113.00 | |
10 mg | In stock | 185.00 |
Description | Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1]. |
Targets&IC50 | EGFR, |
Molecular Weight | 934.51 |
Formula | C47H57ClFN7O8S |
CAS No. | 2230821-27-7 |
0-4℃ for short term (days to weeks), or -20℃ for long term (months).
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.