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Gefitinib-based PROTAC 3

Catalog No. T5437 CAS 2230821-27-7

Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1].

Gefitinib-based PROTAC 3, CAS 2230821-27-7

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5 mg	In stock	113.00
10 mg	In stock	185.00

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Purity 98.25%

HNMR HPLC COA Datasheet

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Description	Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1].
Targets&IC50	EGFR,

Molecular Weight	934.51
Formula	C47H57ClFN7O8S
CAS No.	2230821-27-7

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0-4℃ for short term (days to weeks), or -20℃ for long term (months).

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( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 201. Jan 18;25(1):67-77.e3.

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