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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1802 | ZLN005 | Autophagy | |
ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α. | |||
T4353 | SR-18292 | SR 18292 | Autophagy |
SR-18292 is an inhibitor of PPAR gamma coactivator-1α (PGC-1α), which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes. | |||
T11230 | ERRα antagonist-1 | ERR+/- antagonist-1,ERRa antagonist-1 | Estrogen/progestogen Receptor |
ERRα antagonist-1 (ERR+/- antagonist-1) is a high-affinity, selective antagonist of the estrogen-related receptor α (ERRα). It effectively prevents the interaction of ERRα with both Proliferator-activated Receptor γ Coac... | |||
T7535 | RGX-202 | β-GPA,3-Guanidinopropionic Acid | AMPK , PPAR |
RGX-202 (β-GPA) is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coac... | |||
T4956 | Tetrahydroxystilbene-2-O-β-D-glucoside | tetrahydroxyl diphenylethylene-2-o-gluco,EH-201 | Others |
Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astroc... | |||
TN1677 | Gartanin | BCL , Caspase , JNK | |
Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±sign... | |||
T16342 | KL1333 | NQO1 activator 1 | NADPH , Mitochondrial Metabolism |
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 ... | |||
T72907 | Ac-SVVVRT-NH2 | ||
Ac-SVVVRT-NH2, a PGC-1α modulator, enhances the activity of the human PGC-1α promoter (114%), elevates PGC-1α mRNA levels (125%), and promotes intracellular lipid accumulation (128%) in subcutaneous human adipocytes. Thi... | |||
T75666 | Mogroside VI B | ||
Mogroside VI B, a cucurbitane glucoside derived from Siraitia grosvenorii crude extract, exhibits potency in activating PGC-1α transcription [1]. | |||
T80424 | Phoenixin-20 TFA | PNX-20 TFA | Epigenetic Reader Domain |
Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide that exerts hormone-like effects in vertebrates, stimulating hypothalamo-pituitary-gonadal hormones and regulating mammalian reproductive processes. Additionally, ... | |||
T80423 | Phoenixin-20 | PNX-20 | Epigenetic Reader Domain |
Phoenixin-20 (PNX-20) is a vertebrate bioactive peptide exhibiting hormone-like actions, stimulating the hypothalamo-pituitary-gonadal axis to regulate mammalian reproduction. It enhances neuronal mitochondrial biogenesi... | |||
T79965 | 11-Oxoisomogroside V | ||
11-Oxoisomogroside V (compound 3), a cucurbitacin derived from Luo Han Guo extract, enhances the transcriptional activity of PGC-1α. Luciferase assay data demonstrates that at concentrations of 10 μM and 20 μM, 11-Oxoiso... |