Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 31.00 | |
10 mg | In stock | $ 51.00 | |
25 mg | In stock | $ 92.00 | |
50 mg | In stock | $ 178.00 | |
100 mg | In stock | $ 288.00 | |
200 mg | In stock | $ 433.00 | |
500 mg | In stock | $ 688.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 34.00 |
Description | ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α. |
In vitro | ZLN005 (15 mg/kg, p.o.) exhibits anti-hyperglycemic and anti-hyperlipidemic effects, and enhances insulin sensitivity in db/db mice without effecting lean mice. |
In vivo | In L6 myotubes, ZLN005 enhances glucose uptake and fatty acid oxidation by activating AMP-activated protein kinase (AMPK), and it elevates the expression of PGC-1α genes and downstream genes without significant toxicity. However, the same effects are not observed in primary rat hepatocytes, indicating cell-specific actions. |
Molecular Weight | 250.34 |
Formula | C17H18N2 |
CAS No. | 49671-76-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 2 mg/mL (7.98 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 35 mg/mL (139.8 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ZLN005 49671-76-3 Autophagy Metabolism inhibit ZLN 005 Inhibitor PPARγ coactivator-1α PGC-1α ZLN-005 inhibitor