p2x4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T14844	BX430		P2X Receptor , Calcium Channel
	BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity.		P2X Receptor , Calcium Channel
T12568	PSB-12062	N-(p-Methylphenylsulfonyl)phenoxazine	P2X Receptor
	PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine) is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).		P2X Receptor
T22518	5-BDBD		P2X Receptor
	5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG.		P2X Receptor
T10466	BAY-1797		P2X Receptor
	BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displays no or very weak activity on the other P2X ion channels.		P2X Receptor
T8946	Indophagolin		P2X Receptor , 5-HT Receptor , Autophagy
	Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.		P2X Receptor , 5-HT Receptor , Autophagy
T7881	CTP disodium dihydrate		P2X Receptor
	CTP disodium dihydrate is an agonist of P2X4 purinergic receptor		P2X Receptor
T1131	Ivermectin	MK-933	Mitophagy , GluCls , P2X Receptor , SARS-CoV , HIV Protease , Antibiotic , Parasite , Autophagy , HSV
	Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T16564	PPADS tetrasodium		P2X Receptor , Na+/Ca2+ Exchanger
	PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma in...		P2X Receptor , Na+/Ca2+ Exchanger
T73452	MRS4596
	MRS4596, a potent and selective antagonist of the P2X4 receptor, exhibits an IC50 of 1.38 μM for the human P2X4 receptor. This compound demonstrates both neuroprotective and neuro-rehabilitative effects in ischemic strok...
T73453	MRS4719
	MRS4719, a potent P2X4 receptor antagonist, exhibits a half-maximal inhibitory concentration (IC50) of 0.503 μM for the human P2X4 receptor. Demonstrating both neuroprotective and neuro-rehabilitative effects, it can dec...
T71950	PSB-12054
	PSB-12054 is a potent P2X4 receptor inhibitor. PSB-12054 has IC(50) of 0.189 μM and good selectivity versus the other human P2X receptor subtypes.
T38444	α,β-Methylene-ATP dilithium
	α,β-Methylene ATP dilithium, a phosphonic analog of ATP, serves as a ligand for P2X3 and P2X7 receptors. It is a potent agonist specifically targeting P2X1 and P2X3 receptors while exerting negligible activity on P2X2, P...
TP2272	NF023 hexasodium	NF 023,NF 023 hexasodium	P2X Receptor
	NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively.		P2X Receptor
T64078	MRS2179 tetrasodium hydrate
	MRS2179 tetrasodium hydrate, a competitive antagonist of the P2Y1 receptor, acts on the turkey P2Y1 receptor (Kb: 102 nM, pA2: 6.99) and exhibits an inhibitory effect on platelet aggregation. IC50: 1.15 μM), P2X3 (IC50: ...
T72590	α,β-Methylene-ATP
	α,β-Methylene ATP, a phosphonic analog of ATP, functions as a ligand for P2X3 and P2X7 receptors. This compound acts primarily as a selective agonist for P2X1 and P2X3 receptors, exhibiting minimal to no activity on P2X2...
T83802	TNP-ATP sodium
	TNP-ATP, a derivative of ATP, acts as an antagonist to the purinergic P2Y1, P2X3, and P2X2/3 receptors, demonstrating selectivity by showing lower inhibitory concentrations (IC50 = 6, 0.9, 7 nM, respectively) compared to...