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Indophagolin

Indophagolin
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Purity:97.84%
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Indophagolin

Catalog No. T8946Cas No. 1207660-00-1
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.
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Pack SizePrice/USDAvailabilityQuantity
1 mg$113In Stock
2 mg$158In Stock
5 mg$233In Stock
10 mg$351In Stock
25 mg$593In Stock
50 mg$846In Stock
100 mg$1,170In Stock
1 mL x 10 mM (in DMSO)$285In Stock
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Product Introduction

Bioactivity
Description
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.
In vitro
Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells.Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7.
Chemical Properties
Molecular Weight523.75
FormulaC19H15BrClF3N2O3S
Cas No.1207660-00-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 25 mg/mL (47.73 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9093 mL9.5465 mL19.0931 mL95.4654 mL
5 mM0.3819 mL1.9093 mL3.8186 mL19.0931 mL
10 mM0.1909 mL0.9547 mL1.9093 mL9.5465 mL
20 mM0.0955 mL0.4773 mL0.9547 mL4.7733 mL

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