Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 113.00 | |
2 mg | In stock | $ 158.00 | |
5 mg | In stock | $ 233.00 | |
10 mg | In stock | $ 351.00 | |
25 mg | In stock | $ 593.00 | |
50 mg | In stock | $ 846.00 | |
100 mg | In stock | $ 1,170.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 285.00 |
Description | Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. |
Targets&IC50 | P2X1:2.40μM , P2X3:3.49 μM , P2X4:2.71μM |
In vitro | Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells.Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7. |
Molecular Weight | 523.75 |
Formula | C19H15BrClF3N2O3S |
CAS No. | 1207660-00-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (47.73 mM)
You can also refer to dose conversion for different animals. More
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Indophagolin 1207660-00-1 Autophagy GPCR/G Protein Membrane transporter/Ion channel Neuroscience 5-HT Receptor P2X Receptor inhibit formation Inhibitor 5-hydroxytryptamine Receptor autophagosome Serotonin Receptor P2XRs membrane-bound indoline-based class inhibitor