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Indophagolin

Catalog No. T8946   CAS 1207660-00-1

Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.

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Indophagolin, CAS 1207660-00-1
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.
Targets&IC50 P2X1:2.40μM , P2X3:3.49 μM , P2X4:2.71μM
In vitro Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells.Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7.
Molecular Weight 523.75
Formula C19H15BrClF3N2O3S
CAS No. 1207660-00-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Carnero Corrales MA, et al. Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin [published online ahead of print, 2021 Mar 9]. Cell Chem Biol. 2021;S2451-9456(21)00102-1.

Related compound libraries

This product is contained In the following compound libraries:
Autophagy Compound Library Inhibitor Library Neuronal Signaling Compound Library Bioactive Compound Library

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Keywords

Indophagolin 1207660-00-1 G蛋白偶联受体 离子通道 神经科学 自噬 5-HT Receptor Autophagy P2 Receptor P2X Receptor inhibit formation Inhibitor 5-hydroxytryptamine Receptor autophagosome Serotonin Receptor P2XRs membrane-bound indoline-based class inhibitor