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Ivermectin

Ivermectin
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Purity:97.74%
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Ivermectin

Catalog No. T1131Cas No. 70288-86-7
Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
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Pack SizePriceAvailabilityQuantity
200 mg$32In Stock
500 mg$53In Stock
1 g$72In Stock
1 mL x 10 Mm (in DMSO)$57In Stock
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Product Introduction

Bioactivity
Description
Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
In vitro
Ivermectin exhibits antiviral activity against HIV-1 and Dengue fever virus. It binds to a novel site on GABAA receptors in hippocampal embryonic neurons of mice, conformationally enhancing the affinity of the GABA binding site. In nematodes, the compound interacts with glutamate-gated chloride channels (GluCls), disrupting the regulation mediated by GluCl activity.
In vivo
Intraperitoneal injection of Ivermectin (1.25-10 mg/kg) can reduce the consumption of alcohol and saccharin. For mice exposed to lethal doses of LPS, Ivermectin inhibits LPS-induced NF-kB translocation and enhances survival rates.
AliasMK-933
Chemical Properties
Molecular Weight875.09
FormulaC48H74O14
Cas No.70288-86-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 27 mg/mL (30.9 mM)
DMSO: 45 mg/mL (51.42 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM1.1427 mL5.7137 mL11.4274 mL57.1370 mL
5 mM0.2285 mL1.1427 mL2.2855 mL11.4274 mL
10 mM0.1143 mL0.5714 mL1.1427 mL5.7137 mL
20 mM0.0571 mL0.2857 mL0.5714 mL2.8568 mL
DMSO
1mg5mg10mg50mg
50 mM0.0229 mL0.1143 mL0.2285 mL1.1427 mL
100 mM0.0114 mL0.0571 mL0.1143 mL0.5714 mL

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For example, your dosage is 10 mg/kg,each TargetMol | Animal experiments animal weighs 20 g, and the dosage volume is 100 μL. A total of TargetMol | Animal experiments 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.
Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
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