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NF023 hexasodium

Catalog No. TP2272 CAS 104869-31-0

Synonyms: NF 023, NF 023 hexasodium

NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, < 50 μM and < 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively.

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NF023 hexasodium, CAS 104869-31-0

Pack Size	Availability	Price/USD	Quantity
10 mg	35 days	$ 448.00
25 mg	35 days	$ 984.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively.
In vitro	NF023 demonstrates selectivity for recombinant Gi alpha-1 and recombinant Go alpha, with an EC50 value around 300 nM. It inhibits P2X1 receptors independent of voltage changes. At concentrations of 5 and 30 μM, NF023 induces a rightward shift in the concentration-response curve for ATP without altering the maximal response, indicating an inhibitory effect with a KB value of 1.190.2 μM.
In vivo	NF023 (100 µmol/kg i.v.) inhibits the vasopressor responses triggered by α,β-mATP without affecting those induced by noradrenaline in pithed rats[3].

Synonyms	NF 023, NF 023 hexasodium
Molecular Weight	1168.92
Formula	C35H26N4Na6O21S6
CAS No.	104869-31-0

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 105.3mg/mL (90.1mM)

References and Literature

1. F Soto, et al. Antagonistic Properties of the Suramin Analogue NF023 at Heterologously Expressed P2X Receptors. Neuropharmacology. 1999 Jan;38(1):141-9. 2. M Freissmuth, et al. Suramin Analogues as Subtype-Selective G Protein Inhibitors. Mol Pharmacol. 1996 Apr;49(4):602-11. 3. G Lambrecht, et al. Agonists and Antagonists Acting at P2X Receptors: Selectivity Profiles and Functional Implications. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):340-50. 4. M Silva-Ramos, et al. Activation of Prejunctional P2x2/3 Heterotrimers by ATP Enhances the Cholinergic Tone in Obstructed Human Urinary Bladders. J Pharmacol Exp Ther. 2020 Jan;372(1):63-72.

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Keywords

NF023 hexasodium 104869-31-0 Membrane transporter/Ion channel Neuroscience P2X Receptor NF 023 NF023 NF-023 NF 023 hexasodium NF 023 hexasodium inhibitor inhibit

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