neutralizing — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9911	Tocilizumab		Interleukin
	Tocilizumab (anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor		Interleukin
T74793	USP28-IN-3		DUB
	USP28-IN-3 is a highly selective USP28 inhibitor with an IC50 value of 0.1 μM against USP28.USP28-IN-3 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3, and UCHL5.USP28-IN-3 is cytotoxic to human ...		DUB
T9962	Mepolizumab	SB 240563	IL Receptor
	Mepolizumab (SB 240563) is a humanized monoclonal antibody neutralizing IL-5. Mepolizumab can be used in studies about severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis.		IL Receptor
TP2266L	LF 11 acetate	LF 11 acetate(832729-13-2 Free base)	Antibacterial
	LF 11 acetate exhibits antibacterial activities and can be used for the development of endotoxin-neutralizing and antibacterial agents.		Antibacterial
T73695	Canakinumab	ACZ 885,Ilaris	IL Receptor
	Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody.Canakinumab has been shown to inhibit human and chorioallantoic monkey IL-1β, with IC50 values of 43.6 and 40.8 pM, respectively.Canakinumab...		IL Receptor
T2719	Succinic acid	Asuccin,Amber acid,1,2-Ethanedicarboxylic acid,Wormwood acid,Butanedioic acid,1,4-Butandioic Acid	Endogenous Metabolite
	Succinic acid (1,2-Ethanedicarboxylic acid) is a water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is al...		Endogenous Metabolite
T74485	STC314		Others
	STC314 is an anti-infective agent that reverses organ damage caused by excessive immune response by neutralizing extracellular histones and neutrophil trapping networks, and can be used in the study of sepsis and acute r...		Others
T76883	Talacotuzumab	CSL 362,JNJ 56022473	Immunology/Inflammation related , Interleukin
	Talacotuzumab (JNJ 56022473) is an IgG1 fully humanized CD123 neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has a high affinity for CD123, CD32b/c, CD16-158F and CD16-158V, with KD of...		Immunology/Inflammation related , Interleukin
T15625	JNJ4796		Others
	JNJ4796 is an oral active fusion inhibitor of the influenza virus, by inhibiting hemagglutinin (HA)-mediated fusion to neutralizing the influenza A group 1 virus. JNJ4796 mimics the functionality of the broadly neutraliz...		Others
TN4247	Ikshusterol 3-O-glucoside		Phospholipase
	Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.		Phospholipase
T36651	Anti-MERS-2E6 mAb	Anti-MERS-2E6 mAb
	Anti-MERS-2E6 mAb (MERS-2E6), a human IgG1 neutralizing antibody, is expressed in CHO cells. It effectively competes with the virus Spike protein for binding to the CD26 receptor, consequently inhibiting viral invasion i...
T82372	Free radical scavenger 1
	Compound 8, a free radical scavenger, exhibits an IC50 value of 43.39 μg/ml in neutralizing the DPPH radical [1].
T77177	Elipovimab
	Elipovimab, a potent and broadly neutralizing antibody against HIV-1, targets and eliminates HIV-infected cells [1].
T77005	Felvizumab
	Felvizumab (SB 209763), a humanized IgG1κ monoclonal antibody, targets specific neutralizing epitopes on the F glycoprotein of Respiratory Syncytial Virus (RSV) [1] [2].
T80863	Visugromab	CTL-002	PD-1/PD-L1
	Visugromab, a GDF-15 neutralizing IgG4 monoclonal antibody (mAb), demonstrates potent efficacy in treating PD-1/PD-L1 relapsed/refractory metastatic solid tumors [1].		PD-1/PD-L1
T82482	ELDKWA
	ELDKWA, a highly conserved sequence of amino acids located on the ecto-domain of gp41, serves as the epitope for mAb 2F5, a neutralizing monoclonal antibody against human immunodeficiency virus type 1 [1] [2].
T76820	Namilumab
	Namilumab (AMG203), a human IgG1 monoclonal antibody, exhibits high affinity binding to the GM-CSF ligand, effectively neutralizing GM-CSF. It has potential application in researching rheumatoid arthritis [1].
T77063	Libivirumab
	Libivirumab (17.1.41), a humanized monoclonal antibody targeting hepatitis B virus (HBV), demonstrates neutralizing activity with half maximal inhibitory concentrations (IC50) of 35 ng/mL for HBsAg and 130 ng/mL for HBeA...
T76999	Cilgavimab
	Cilgavimab (AZD-1061; COV2-2130), a humanized SARS-CoV-2-neutralizing monoclonal antibody, forms part of the monoclonal antibody combination AZD7442 with Tixagevimab. It demonstrates protective effects in mouse models of...
T80909	Tyrosinase-IN-19		Tyrosinase
	Tyrosinase-IN-19 (compound 9), a competitive tyrosinase inhibitor, exhibits potent antioxidant activities by neutralizing ROS, ABTS+, and DPPH radicals and demonstrates dose-dependent suppression of tyrosinase expression...		Tyrosinase