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JNJ4796

Catalog No. T15625 CAS 2241664-16-2

JNJ4796 is an oral active fusion inhibitor of the influenza virus, by inhibiting hemagglutinin (HA)-mediated fusion to neutralizing the influenza A group 1 virus. JNJ4796 mimics the functionality of the broadly neutralizing antibodies (bnAbs).

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JNJ4796, CAS 2241664-16-2

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 2,120.00
50 mg	8-10 weeks	$ 2,780.00
100 mg	8-10 weeks	$ 3,700.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	JNJ4796 is an oral active fusion inhibitor of the influenza virus, by inhibiting hemagglutinin (HA)-mediated fusion to neutralizing the influenza A group 1 virus. JNJ4796 mimics the functionality of the broadly neutralizing antibodies (bnAbs).
Targets&IC50	H1/Cal:66 nM(EC50), H1/PR8:22 nM(EC50), H5/Viet:3.24 μM（EC50）, H1/Bris:(EC50)12 nM, H1/SI06:13 nM（EC50）, H5/H97:449 nM（EC50）, H1/NCa:38 nM(EC50)
In vitro	The mechanism of action of JNJ4796 is demonstrated to be based on inhibition of the pH-sensitive conformational change of HA, like bnAb CR6261. That triggers the fusion of the viral and endosomal membranes and the release of the viral genome into the host cell[1].
In vivo	JNJ4796(50 and 10 mg/kg; twice daily) treatment, initiated one day before the challenge and continuing for 7 days, results in 100% survival at day 21 in comparison to the less potent compound JNJ8897 for which less than 50% survival is achieved. JNJ4796 (p.o.) protects mice from lethal challenge of 25 times the median lethal dose (LD50) of H1N1 A/Puerto Rico/8/1934 virus. Oral doses of JNJ4796 cause dose-dependent efficacy after a sublethal viral challenge (LD90), with twice-daily administration of 15 and 5 mg/kg of JNJ4796 giving rise to 100% survival[1].

Molecular Weight	537.57
Formula	C28H27N9O3
CAS No.	2241664-16-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. van Dongen MJP, et al. A small-molecule fusion inhibitor of influenza virus is orally active in mice. Science. 2019 Mar 8;363(6431).

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JNJ4796 2241664-16-2 Others JNJ-4796 JNJ 4796 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.