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Search Result

Search Results for " nef "

Targets

HIV Protease

20

Compounds

2

Natural Products

10

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T9039 HIV-1 Nef-IN-1 HIV Protease
HIV-1 Nef-IN-1 is an inhibitor of HIV-1 Nef protein. It efficiently competes for Nef-SH3Hck interactions(Kd : 6.7 μM).
T11538 Hck-IN-1 HIV Protease , Src , Hck
Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for w...
T0169 Nefiracetam DM9384,DZL-221 GABA Receptor
Nefiracetam (DM9384) are underway in Phase 2 trials. Nefiracetam, a GABAergic、 cholinergic、and monoaminergic neuronal system enhancer, is used for Ro 5-4864-induced convulsions.
T16886 Sinefungin Adenosyl-Ornithine,A-9145,Antibiotic 32232RP Others , Histone Methyltransferase , Antibiotic , Antifungal
Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates r...
T0470 Nefopam hydrochloride Fenazoxine hydrochloride,Nefopam HCl Wnt/beta-catenin , Sodium Channel
Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.
T6089 Neflamapimod VX-745 p38 MAPK , Autophagy
Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.
T3275 Nefazodone hydrochloride Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754 5-HT Receptor , Adrenergic Receptor
Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.
T19454 N-Desmethylnefopam Others
N-Desmethylnefopam is the main Nefopam metabolite .
T126388 9-Oxotournefortiolide, Tourneforin
9-Oxotournefortiolide, Tourneforin is a useful organic compound for research related to life sciences. The catalog number is T126388 and the CAS number is 111420-61-2.
T19453 N-Desmethylnefopam D5 hydrochloride Others
N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride.
T71821 Norfenefrine HCl
Norfenefrine is an Adrenergic Agonist. It is used in the treatment of female stress incontinence.
T21451 Nefazodone Nefadar,Dutonin,Serzone
Nefazodone is an antidepressant. It has low affinity for the serotonin (200 nM), dopamine (360 nM), and norepinephrine (360 nM) transporters, and therefore acts as a weak serotonin-norepinephrine-dopamine reuptake inhibi...
T67197 9-methylidenefluorene
Fluorenylidenemethane is an analogue of a 1,1-Diphenylethylene. Polymerization of Fluorenylidenemethane produces a π-stacked polymer.
T12788 R(+)-IAA-94 R(+)-Methylindazone Chloride channel
R(+)-IAA-94 (R(+)-Methylindazone) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-IAA-94 inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef).
T61793 HIV-IN-6 HIV Protease
HIV-IN-6 is an HIV viral inhibitor that inhibits the replication of the HIV virus.HIV-IN-6 has anti-HIV viral activity and works by targeting Src family kinases (SFK) (e.g., Hck) that interact with the viral Nef protein.
T29217 ZINC04177596
ZINC04177596 is a novel Nef Protein Inhibitor with anti-HIV activity.
T29222 ZINC36617540
ZINC36617540 is a novel Nef Protein Inhibitor with anti-HIV activity.
T68637 NSC13987
NSC13987 is an inhibitor of Nef-calnexin interaction.
T24017 DQBS
DQBS is an HIV-1 Nef function antagonist.
T31545 DLC27-14 DLC-2714,DLC 2714,DLC2714
DLC27-14 is an HIV-1 Nef specific protein disorder catalyzer.
Cat No. Product Name Synonyms Targets
T5S1097 Neferine (R)-1,2-Dimethoxyaporphine,(-)-Neferine Apoptosis , NF-κB , Autophagy
1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to a...
TN2482 1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid Others
1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid is a natural product for research related to life sciences. The catalog number is TN2482 and the CAS number is 69251-99-6.

Natural Products

Neferine
T5S1097
Synonym: (R)-1,2-Dimethoxyaporphine,(-)-Neferine
Target: Apoptosis, NF-κB, Autophagy
1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid
TN2482
Synonym:
Target: Others

Recombinant Proteins

Species：
Human (7)
Canine (1)
Mouse (1)
Rat (1)
Expression System：
E. coli (7)
HEK293 Cells (2)
P. pastoris (Yeast) (1)
Tag：
N-10xHis, C-Myc (2)
N-hFc (2)
C-6xHis-SUMO (1)
His (1)
His, MBP (1)
N-10xHis-SUMO, C-Myc (1)
N-6xHis (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPY-02531 S100B Protein, Human, Recombinant (His) Human E. coli
S100B Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12 kDa and the accession number is A0A0S2Z4C5.
TMPY-00913 S100B Protein, Human, Recombinant (hFc) Human HEK293 Cells
S100B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 37.2 kDa and the accession number is A0A0S2Z4C5.
TMPK-01369 S100B Protein, Canine, Recombinant (hFc) Canine HEK293 Cells
S100B, a calcium-binding protein of the EF-hand type exerts both intracellular and extracellular functions.The intracellular, and extracellular, roles of S100B are attractive therapeutic targets for the treatment of both...
TMPH-03340 NEFH Protein, Rat, Recombinant (His & Myc) Rat E. coli
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by...
TMPH-02805 NEFL Protein, Mouse, Recombinant (His) Mouse P. pastoris (Yeast)
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament prot...
TMPH-01757 NEFH Protein, Human, Recombinant (His & Myc & SUMO) Human E. coli
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by...
TMPH-01758 NEFL Protein, Human, Recombinant Human E. coli
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament prot...
TMPH-01759 NEFL Protein, Human, Recombinant (His & SUMO) Human E. coli
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament prot...
TMPH-01760 NEFM Protein, Human, Recombinant (His & Myc) Human E. coli
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament prot...
TMPY-00587 GABARAP Protein, Human, Recombinant (His & MBP) Human E. coli
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in...
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