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Search Results for " nck "

Targets

9

Compounds

1

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T77719 TNIK-IN-7 Wnt/beta-catenin
TNIK-IN-7 is a potent and selective Traf2 and Nck interacting kinase (TNIK) inhibitor (IC50: 11 nM) with antitumor activity for studying signaling and proliferation in colorectal cancer cells.
T9557 TNIK-IN-2 Wnt/beta-catenin
TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
T9556 TNIK-IN-3 Wnt/beta-catenin
TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK). It exhibits a strong selectivity for TNIK with an IC50 value of 0.026 μM. Additionally, TNIK-IN-3 demonstrates...
T11793 KY-05009 Wnt/beta-catenin
KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o...
T4403 AX-024 hydrochloride AX-024 HCl IL Receptor , TNF , COX , IFNAR , Interleukin
AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.
T26282 TNIK-IN-1 TNIK-inhibitor-1,TNIK inhibitor 1
TNIK-IN-1 is an inhibitor of Traf2- and Nck-interacting kinase (TNIK).
T80971 TNIK-IN-6
TNIK-IN-6 (Compound 9) acts as an inhibitor of Traf2 and Nck-interacting kinase (TNIK), exhibiting an inhibitory concentration (IC50) of 0.93 μM, a kinase implicated in various neurological and psychiatric disorders [1] ...
T61071 AX-024
AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. Wi...
T10898 Samuraciclib hydrochloride ICEC0942 hydrochloride,CT7001 hydrochloride Apoptosis , CDK
Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h...
Cat No. Product Name Synonyms Targets
T5S1981 Alpha-Cyperone (+)-α-Cyperone,α-Cyperone Others , Endogenous Metabolite
1. alpha-Cyperone (α-Cyperone) is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. 2. alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00870 NCK1 Protein, Human, Recombinant (His) Human E. coli
Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, ...
TMPY-03435 NCKIPSD Protein, Human, Recombinant (GST) Human E. coli
NCKIPSD is localized exclusively in the cell nucleus. It plays a role in signal transduction and may function in the maintenance of sarcomeres and the assembly of myofibrils into sarcomeres. NCKIPSD also plays an importa...
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