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TNIK-IN-2

Name: TNIK-IN-2
Brand: TargetMol
SKU: T9557
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9557Cas No. 2754265-76-2

TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.

TNIK-IN-2

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Purity: 99.54%

Catalog No. T9557Cas No. 2754265-76-2

TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.

Pack Size	Price	Availability
1 mg	$74	In Stock
5 mg	$181	In Stock
10 mg	$289	In Stock
25 mg	$476	In Stock
50 mg	$678	In Stock
100 mg	$912	In Stock
1 mL x 10 mM (in DMSO)	$189	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.54%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which is a downstream signal protein of the Wnt/β-catenin pathway.
Targets&IC50	TNIK:1.33 μM, TNIK:31.26 μM(HCT116 cells)
In vitro	In HCT116 cells, the IC50 value was 31.26 μM for TNIK[1].

Chemical Properties

Molecular Weight	373.4
Formula	C₂₂H₁₉N₃O₃
Cas No.	2754265-76-2
Smiles	O(C)C=1C=C(C=2C=C3C(=NC2)NC=C3)C=CC1C(NC4=CC(OC)=CC=C4)=O
Relative Density.	1.299 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (133.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6781 mL	13.3905 mL	26.7809 mL	133.9047 mL
5 mM	0.5356 mL	2.6781 mL	5.3562 mL	26.7809 mL
10 mM	0.2678 mL	1.3390 mL	2.6781 mL	13.3905 mL
20 mM	0.1339 mL	0.6695 mL	1.3390 mL	6.6952 mL
50 mM	0.0536 mL	0.2678 mL	0.5356 mL	2.6781 mL
100 mM	0.0268 mL	0.1339 mL	0.2678 mL	1.3390 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc