nafld — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3804	Neomangiferin	Mangiferin 7-glucoside	Phosphatase
	Neomangiferin (Mangiferin 7-glucoside) has beneficial effects on high fat diet-induced nonalcoholic fatty liver disease in rats. Neomangiferin and mangiferin inhibit tartrate-resistant acid phosphatase, a biochemical mar...		Phosphatase
T14002	12-Ketodeoxycholic acid		Endogenous Metabolite
	12-Ketodeoxycholic acid, a bile acid and kidney metabolite, serves as a detectable marker for kidney injury [1].		Endogenous Metabolite
T2601	Vidofludimus	SC12267,4sc-101	Dehydrogenase , DNA/RNA Synthesis , Interleukin
	Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).		Dehydrogenase , DNA/RNA Synthesis , Interleukin
T9010	IMM-H007		Others , AMPK
	IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression		Others , AMPK
T27460	GSK2324	GSK-2324,GSK 2324	FXR
	GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.		FXR
T7294	Aramchol	C20-FABAC	Others
	Aramchol (C20-FABAC), also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid and cholic acid. It reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholester...		Others
T78093	Cisd2 agonist 1		Others
	Cisd2 agonist 1 (Compound 4q), with an EC50 of 34 nM, augments Cisd2 expression and ameliorates pathological alterations in fatty liver disease, demonstrating good metabolic stability. This compound is utilized in non-al...		Others
T78313	Fazpilodemab	BFKB8488A	FGFR
	Fazpilodemab (BFKB8488A) is a humanized agonistic bispecific antibody that targets fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ. It is utilized in research pertaining to Type 2 diabetes mellitus (T2DM) and n...		FGFR
T74132	GLP-1 receptor agonist 8
	GLP-1 receptor agonist 8, a potent agonist of GLP-1 R, holds potential for diabetes, obesity, and nonalcoholic fatty liver disease (NAFLD) research[1].
T75150	GIP/GLP-1 dual receptor agonist-1
	GIP/GLP-1 dual receptor agonist-1 (compound 4), a receptor agonist for both GIP and GLP-1, shows potential for the research of metabolic disorders and fatty liver diseases, such as nonalcoholic steatohepatitis (NASH) and...
T62029	ML261
	ML261 is a inhibitor of hepatic lipid droplets formation with an IC 50 of 69.7 nM. ML261 has research value in non-alcoholic fatty liver disease (NAFLD) and inflammation.
T62277	PPARδ agonist 8
	Pparδ agonist 8 is a potent agonist of Pparδ. Pparδ agonist 8 has potential for the study of nonalcoholic fatty liver disease (NAFLD).
T82719	Cisd2 agonist 2
	Cisd2 agonist 2 (compound 6), with an EC50 of 191 nM, is an orally active activator of Cisd2, a protein whose levels are associated with nonalcoholic fatty liver disease (NAFLD). In vivo studies have demonstrated that Ci...
T72889	FXR agonist 4
	FXR agonist 4 with an EC 50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of ...
T78095	Demethyleneberberine chloride		NF-κB
	Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-κB pathway and modulating the equilibrium of Th cells. It is ...		NF-κB
T35443	1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol
	1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol is a triacylglycerol that contains palmitic , stearic , and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. It has been detected in RAW 264.7 cells by neutral ...
T82254	GSK-LSD1		Histone Demethylase
	GSK-LSD1, an LSD1 inhibitor, decreases food consumption and body weight while enhancing insulin sensitivity and glycemic regulation in murine obesity models. Additionally, it mitigates non-alcoholic fatty liver disease (...		Histone Demethylase
T62052	AMPK activator 6
	AMPK activator 6 (Compound GC) activates the AMPK pathway and reduces lipid content in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase of total cholesterol (TC), low-density lipoprotein-C (...
T79358	PF-07247685		Endogenous Metabolite
	PF-07247685, a potent BCKDC kinase (BDK) inhibitor (EC 50 = 2.2 nM), enhances the binding between BDK and the BCKDH E2 core subunit to block E1 phosphorylation. BDK regulation is crucial for BCKDH activity, which manages...		Endogenous Metabolite
T79357	PF-07238025		Endogenous Metabolite
	PF-07238025, a potent branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with an EC50 of 19 nM, enhances the stability of the BDK-BCKDH core E2 subunit interaction and inhibits the phosphorylation of the E1 sub...		Endogenous Metabolite