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Aramchol

Catalog No. T7294 CAS 246529-22-6

Synonyms: C20-FABAC

Aramchol (C20-FABAC), also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid and cholic acid. It reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholesterol crystals in a dose-dependent manner.

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Aramchol, CAS 246529-22-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 70.00
10 mg	In stock	$ 125.00
25 mg	In stock	$ 263.00
50 mg	In stock	$ 389.00
100 mg	In stock	$ 573.00
1 mL * 10 mM (in DMSO)	In stock	$ 108.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Aramchol (C20-FABAC), also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid and cholic acid. It reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholesterol crystals in a dose-dependent manner.
In vivo	Three months' administration of the fatty acid-bile acid conjugate Aramchol is significantly reduces liver fat content in patients with NAFLD. The reduction in liver fat content occurred in a dose-dependent manner and was associated with a trend of metabolic improvements, indicating that Aramchol might be used for the treatment of fatty liver disease[1].
Animal Research	Performed a randomized, double-blind, placebo-controlled trial of 60 patients with biopsy-confirmed NAFLD (6 with nonalcoholic steatohepatitis) at 10 centers in Israel. Patients were given Aramchol (100 or 300 mg) or placebo once daily for 3 months (n = 20/group). The main end point was the difference between groups in the change in liver fat content according to magnetic resonance spectroscopy. The secondary end points focused on the differences between groups in alterations of liver enzyme levels, levels of adiponectin, homeostasis model assessment scores, and endothelial function[1].

Synonyms	C20-FABAC
Molecular Weight	702.1
Formula	C44H79NO5
CAS No.	246529-22-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 53.33 mg/mL (75.96 mM)

References and Literature

1. Safadi R , Konikoff F M , Mahamid M , et al. The Fatty Acid–Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease[J]. Clinical Gastroenterology and Hepatology, 2014, 12(12):2085-2091.e1. 2. Eshraghian A . Current and emerging pharmacological therapy for non-alcoholic fatty liver disease[J]. World Journal of Gastroenterology, 2017, 23(42):7495-7504.

Citations

1. Xie Y, Zhang L, Wang L, et al.EphB1 promotes the differentiation and maturation of dendritic cells in non-small cell lung cancer.Cancer Letters.2023: 216567.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compound Library Anti-Fibrosis Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Clinical Compound Library

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Keywords

Aramchol 246529-22-6 Others Inhibitor inhibit C20-FABAC inhibitor

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