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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9232 | Mitochondrial fusion promoter M1 | Mitochondrial Metabolism | |
Mitochondrial fusion promoter M1, a modulator of mitochondrial dynamics, enhances mitochondrial function and cellular respiration, and has shown efficacy in reducing brain and cardiac damage in rats suffering from cardia... | |||
T37657 | Mitochondrial respiration-IN-1 hydrobromide | ||
Mitochondrial respiration-IN-1 hydrobromide (compound 49) is a potent mitochondrial inhibitor (IC50=8.8 mg/mL). Mitochondrial respiration-IN-1 hydrobromide significantly reduces mitochondrial respiration in platelets[1]. | |||
T1907 | Mdivi-1 | Mitochondrial division inhibitor 1 | Apoptosis , Mitophagy , Dynamin , Autophagy |
Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy. | |||
T72137 | Mitochondrial respiration-IN-3 | ||
Mitochondrial respiration-IN-3, a fluorine derivative of Dalfopristin, possesses cell membrane permeability and exhibits the capability to inhibit mitochondrial translation in glioblastoma stem cells. This compound is ut... | |||
T72138 | Mitochondrial respiration-IN-2 | ||
Mitochondrial respiration-IN-2, a fluorine derivative of Virginiamycin M1, inhibits the mitochondrial translation of glioblastoma stem cells [1]. | |||
T8433 | HQNO | Mitochondrial Metabolism | |
HQNO is a natural product isolated from P. aeruginosa,and is a potent inhibitor of electron transport chain(Kd of 64 nM for complex III). It also is a potent mitochondrial NDH-2 inhibitorin many species. | |||
T9372 | D-Histidine | Mitochondrial Metabolism | |
D-Histidine is an enantiomer of L-histidine. L-Histidine is an inhibitor of mitochondrial glutamine transport and also an essential amino acid for infants. | |||
T5S1099 | Liensinine | Apoptosis , Mitophagy , Others , Autophagy | |
1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias. | |||
T1768 | 7ACC2 | Mitochondrial Metabolism , Monocarboxylate transporter | |
7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells. | |||
TN1586 | Dihydrorotenone | Apoptosis , Mitochondrial Metabolism | |
Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. | |||
T9031 | MCU-i4 | Others , Mitochondrial Metabolism | |
MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth. | |||
T15373 | Gboxin | ATPase , Mitochondrial Metabolism | |
Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity. | |||
T9777 | THP104c | Mitochondrial Metabolism | |
THP104c is an inhibitor of mitochondrial fission. | |||
T8732 | CTPI-2 | Others , Mitochondrial Metabolism | |
CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 ha... | |||
T12408 | Perhexiline maleate | Others , Mitochondrial Metabolism | |
Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2 that reduces fatty acid metabolism. The IC50 values of perhexiline maleate against rat heart and liver CPT 1 were 77 and 148 μM, respectively. | |||
T0239 | Lonidamine | AF1890,DICA,Diclondazolic Acid | Apoptosis , Hexokinase , Mitochondrial Metabolism |
Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK). | |||
T14497 | BAM 15 | OXPHOS , Mitochondrial Metabolism | |
BAM 15 is an uncoupler of mitochondrial protonophore. | |||
T15241 | ER-000444793 | Others , Mitochondrial Metabolism | |
ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM). | |||
T5827 | BI-6C9 | Apoptosis , Others , Mitochondrial Metabolism | |
BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death. | |||
T6157 | Devimistat | CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid | Apoptosis , Dehydrogenase , Mitochondrial Metabolism |
Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potent... |