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Mdivi-1

Catalog No. T1907 CAS 338967-87-6

Synonyms: Mdivi 1, Mitochondrial division inhibitor 1

Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) (IC50: 1-10 μM).

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Mdivi-1, CAS 338967-87-6

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Purity: 98%

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Description	Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) (IC50: 1-10 μM).
Targets&IC50	Dnm1 GTPase:1 μM-10 μM
Kinase Assay	All GTPase assay reactions are started in a 200 μL volume, of which 150 μL is placed into the well of a 96-well plate. Depletion of NADH, as monitored by reading the A340 of the reaction, is measured every 20 s for a total of 40 min using a SpectraMAX 250 96-well plate reader. Spectrophotometric data are transferred to Excel and the measured steady state depletion of NADH over time is converted to protein activity.
Cell Research	Mdivi-1 is dissolved in DMSO. YPGlycerol plates are topped with 10 mL YPGlycerol containing 1% low melt agar and 75 μM mdivi-1, and cells are spotted 12 hours later using a 48 well pinning device. After pinning cells, plates are incubated at 24°C or 37°C and imaged using an Eagle Eye II imaging system.

Synonyms	Mdivi 1, Mitochondrial division inhibitor 1
Molecular Weight	353.22
Formula	C15H10Cl2N2O2S
CAS No.	338967-87-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 35.3 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Cassidy-Stone A, et al. Dev Cell, 2008, 14(2), 193-204. 2. Park SW, et al. Invest Ophthalmol Vis Sci, 2011, 52(5), 2837-2843. 3. Su Q, Wang J, Liu F, et al. Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis[J]. Toxicology in Vitro. 2020: 104840.

Citations

1. Li Q, Chu Y, Li S, et al. The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization. Cell Death & Disease. 2022, 13(10): 1-16. 2. Guo Q, Zhang Y C, Wang W, et al. Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification. Pharmacological Research. 2022: 106046. 3. Guo Q, Zhang Y C, Wang W, et al. Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification. Pharmacological Research. 2022: 106046. 4. Li C, Pan Y, Tan Y, et al. PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity. Frontiers in cell and developmental biology. 2022, 10. 5. Shi Y, Liu Q, Chen W, et al. Protection of Taohong Siwu Decoction on PC12 cells injured by oxygen glucose deprivation/reperfusion via mitophagy-NLRP3 inflammasome pathway in vitro. Journal of Ethnopharmacology. 2022: 115784. 6. Wang J, Su Q, Wu Q, et al. Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells. Archives of Pharmacal Research. 2021: 1-12. 7. Su Q, Wang J, Liu F, et al. Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis. Toxicology in Vitro. 2020: 104840 8. Su Q, Wu Q, Chen K, et al. Induction of Estrogen Receptor β-mediated Autophagy Sensitizes Breast Cancer Cells to TAD1822-7, a Novel Biphenyl Urea Taspine Derivative. Molecular Biology Reports. 2021

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Inhibitor Library Mitochondria-Targeted Compound Library Immunology/Inflammation Compound Library Covalent Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Apoptosis Compound Library Anti-Aging Compound Library Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mdivi-1 338967-87-6 凋亡细胞骨架自噬 Apoptosis Autophagy Dynamin Mitophagy Mitochondrial Autophagy Mitochondrial division inhibitor1 Inhibitor inhibit Mitochondrial division inhibitor 1 Mdivi 1 Mdivi1 Mitochondrial division inhibitor-1 inhibitor

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