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BAM 15

Catalog No. T14497   CAS 210302-17-3

BAM 15 is an uncoupler of mitochondrial protonophore.

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BAM 15 Chemical Structure
BAM 15, CAS 210302-17-3
Pack Size Availability Price/USD Quantity
5 mg In stock $ 59.00
10 mg In stock $ 109.00
25 mg In stock $ 197.00
50 mg In stock $ 328.00
100 mg In stock $ 497.00
500 mg In stock $ 1,080.00
1 mL * 10 mM (in DMSO) In stock $ 66.00
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Purity: 99.89%
Purity: 99.75%
Purity: 99.73%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BAM 15 is an uncoupler of mitochondrial protonophore.
In vitro BAM 15 is fully capable of increasing mitochondrial respiration in the presence of oligomycin which does so across a broader concentration range than FCCP in both myoblasts and hepatocytes and it is capable to increase O2 consumption across a broad dosing range without increasing ROS. BAM 15 and FCCP are structurally unrelated. Which is observed that low doses of BAM 15 from 100 nM to 1 μM increase cellular O2 consumption rate (OCR) to a similar degree as FCCP, However higher concentrations from 1 μM to 50 μM reveal that BAM 15 is able to maintain uncoupled respiration at a high rate in a range of cell lines. BAM 15 induces mitochondrial swelling, demonstrating that BAM 15 is a protonophore. BAM15-treated cells are more viable than FCCP-treated cells when administered across a broad dosing range up to 50 μM[1].
In vivo Animals that receive BAM 15 are protected from kidney injury compared to vehicle-treated mice, such as indicated by lower plasma creatinine levels at 24 and 48 h post-ischemia, reduced tubular necrosis, less obstruction of proximal tubules, less depletion of brush border villi, and less immune cell infiltration[1].
Molecular Weight 340.29
Formula C16H10F2N6O
CAS No. 210302-17-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 72 mg/mL (211.58mM), sonification is recommended.

TargetMolReferences and Literature

1. Kenwood BM, et al. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab. 2013 Nov 28;3(2):114-23.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Cuproptosis Compound Library Mitochondria-Targeted Compound Library Apoptosis Compound Library Metabolism Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Anti-Aging Compound Library

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Keywords

BAM 15 210302-17-3 Apoptosis Metabolism OXPHOS Mitochondrial Metabolism inhibit BAM15 BAM-15 Inhibitor inhibitor

 

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