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Dihydrorotenone

Catalog No. TN1586   CAS 6659-45-6

Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.

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Dihydrorotenone Chemical Structure
Dihydrorotenone, CAS 6659-45-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 115.00
5 mg In stock $ 279.00
10 mg In stock $ 443.00
25 mg In stock $ 733.00
50 mg In stock $ 987.00
1 mL * 10 mM (in DMSO) In stock $ 335.00
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Purity: 99.58%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.
In vitro Dihydrorotenone arrested human plasma cancer cells at the G0/G1 phase of the cell cycle. Dihydrorotenone inhibited cyclin D2 transactivation, thus inhibiting its mRNA expression. In addition, Dihydrorotenone upregulated the cell cycle repressors p21 and p53. Dihydrorotenone also increased the phosphorylation level of p53, suggesting the upregulated transactivation function of p53, which was confirmed by the induction of p21, a substrate of activated p53. Moreover, Dihydrorotenone downregulated AKT and ERK phosphorylation, an incentive of cell cycle progression.
Source
Molecular Weight 396.43
Formula C23H24O6
CAS No. 6659-45-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (69.37 mM)

TargetMolReferences and Literature

1. Natural pesticide dihydrorotenone arrests human plasma cancer cells at the G0/G1 phase of the cell cycle.J Biochem Mol Toxicol. 2014 May;28(5):232-8.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Antiparasitic Natural Product Library Anti-Metabolism Disease Compound Library Anti-Parkinson's Disease Compound Library Metabolism Compound Library Reprogramming Compound Library Inhibitor Library Natural Product Library Anti-infective Natural Product Library Endoplasmic Reticulum Stress Compound Library

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Keywords

Dihydrorotenone 6659-45-6 Apoptosis Metabolism Mitochondrial Metabolism inhibit Inhibitor inhibitor

 

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