metin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T33359	Meticillin	Staphcillin,Methicillin,Dimethoxyphenyl Penicillin,Metin
	Methicillin is a narrow-spectrum beta-lactam antibiotic of the penicillin-like family, used to treat infections caused by susceptible gram-positive bacteria, in particular penicillase-producing organisms such as Staphylo...
T15095	Dehydroemetine		Others , Parasite
	Dehydroemetine is an effective antigenic insecticide, which is a synthetic analogue of Emetine dihydrochloride. It can be used to prevent and treat amoeba infections and diseases. It has the effect of treating leishmania...		Others , Parasite
T2550	Tolmetin	Tolectin	COX
	Tolmetin (Tolectin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin is Nonsteroidal Anti-inflammatory Compounds.		COX
T1704	Diosmetin	Luteolin 4-methyl ether	P450 , Trk receptor
	Diosmetin (Luteolin 4-methyl ether) has been found to act as a weak TrkB receptor agonist.		P450 , Trk receptor
T19672	Amtolmetin guacil	MED 15,MED15,ST679,ST-679,ST 679,MED-15	COX
	Amtolmetin guacil (ST-679) inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties.		COX
T6636	Refametinib	BAY 86-97661,BAY 869766,RDEA119	MEK
	Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).		MEK
T6934	Pexmetinib	ARRY-614	Tie-2 , p38 MAPK , Autophagy
	Pexmetinib (ARRY-614) (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.		Tie-2 , p38 MAPK , Autophagy
T16729	Remetinostat	SHP-141	HDAC
	Remetinostat (SHP-141), a hydroxamic acid-based inhibitor of histone deacetylase enzymes, is currently being developed for the treatment of cutaneous T-cell lymphoma.		HDAC
T67911	(Iso)-Dehydroemetine	Dehydroisoemetine, (+/-)-,Dehydroisoemetine	Others
	(Iso)-Dehydroemetine (Dehydroisoemetine, (+/-)-) is a compound with antispasmolytic effect on smooth muscle.		Others
T11047	DiosMetin 7-O-β-D-Glucuronide		Others
	DiosMetin 7-O-β-D-Glucuronide is an antioxidant constituent in the fruits of Luffa cylindrical. The consumption of sponge gourds can supply some antioxidant constituents to the human body.		Others
T12697	Refametinib R enantiomer	RDEA119 R enantiomer,Refametinib R enantiomer,BAY 869766 R enantiomer	MEK
	Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be used in cancer research.		MEK
T2125	Trametinib	GSK1120212,JTP-74057	Apoptosis , MEK , Autophagy
	Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis.		Apoptosis , MEK , Autophagy
T2508	Binimetinib	ARRY-438162,ARRY-162,MEK162	MEK , Autophagy
	Binimetinib (ARRY-162) (MEK162, ARRY-162, ARRY-438162) is an orally available inhibitor of MEK1/2 (IC50: 12 nM) in a cell-free assay.		MEK , Autophagy
T6218	Selumetinib	ARRY-142886,AZD6244	Apoptosis , ERK , MEK
	Selumetinib (AZD6244) (AZD6244) is an effective, specific inhibitor of MEK1 and ERK1/2 phosphorylation (IC50: 14/10 nM).		Apoptosis , ERK , MEK
T16965	Symetine	L 16726	Parasite
	Symetine（L 16726） is a small molecule compound with antiparasitic activity that can be used to study amoebic liver abscesses in guinea pigs.		Parasite
T5414	Glumetinib	SCC244	c-Met/HGFR
	Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).		c-Met/HGFR
T4S0692	Diosmetin-7-O-β-D-glucopyranoside	Diosmetin-7-O-beta-D-glucopyranoside,Eridictiol	Antioxidant
	Diosmetin-7-O-β-D-glucopyranoside (Eridictiol) has antioxidant activity.		Antioxidant
T6189	Mirdametinib	PD325901,PD0325901	Apoptosis , MEK , Autophagy
	Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity. Mirdametinib exhibits antitumor activity by inhibiting p-ERK1/2 expression and inducing apoptosis.		Apoptosis , MEK , Autophagy
T3623	Cobimetinib	RG7420,XL518,GDC-0973	Apoptosis , MEK
	Cobimetinib (GDC-0973) is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of e...		Apoptosis , MEK
T6047	Ralimetinib dimesylate	LY2228820 dimesylate,Ralimetinib,LY2228820,Ralimetinib Mesylate	Apoptosis , p38 MAPK , Autophagy
	Ralimetinib dimesylate (LY2228820 dimesylate) is the dimesylate salt form of LY2228820, a tri-substituted imidazole derivative and orally available, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential an...		Apoptosis , p38 MAPK , Autophagy