mek2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6636	Refametinib	BAY 86-97661,BAY 869766,RDEA119	MEK
	Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).		MEK
T5412	RO4987655	CH4987655,RG7167	MEK
	RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2).		MEK
T2125	Trametinib	GSK1120212,JTP-74057	Apoptosis , MEK , Autophagy
	Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis.		Apoptosis , MEK , Autophagy
T6692	TAK-733	TAK733,TAK 733	MEK
	TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.		MEK
T2623	PD98059	PD 98059	ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy
	PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy.		ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy
T6131	Pimasertib	AS703026,MSC1936369B,SAR 245509	MEK
	Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.		MEK
T6785	BI-847325		Apoptosis , MEK , Aurora Kinase
	BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.		Apoptosis , MEK , Aurora Kinase
T2253	TCS PIM-1 1	SC 204330	Pim
	TCS PIM-1 1 (SC 204330)(sc-204330) is a effective and specific ATP-competitive Pim-1 kianse inhibitor (IC50: 50 nM) , exhibits good specific over MEK1/MEK2 and Pim-2(IC50s >20, 000 nM).		Pim
T6223	U0126-EtOH	U0126 Ethanol,U0126	Mitophagy , Influenza Virus , MEK , Autophagy
	U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).		Mitophagy , Influenza Virus , MEK , Autophagy
T6083	AZD8330	ARRY-424704,ARRY-704	ERK , MEK
	AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.		ERK , MEK
T5857	Trametinib (DMSO solvate)	Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)	Apoptosis , MEK
	Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)		Apoptosis , MEK
T35610	2,5-dimethyl Celecoxib		Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor
	2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ...		Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor
T2708	SL327	SL 327,SL-327	MEK , DNA/RNA Synthesis
	SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.		MEK , DNA/RNA Synthesis
T13782	MS432		MEK
	MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.		MEK
T69826	U-0126
	U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. It was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase M...
T2443	CI-1040	PD 184352	Apoptosis , MEK
	CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM).		Apoptosis , MEK
T15542	Hypothemycin		Others
	Hypothemycin is a fungal polyketide and is a multikinase inhibitor (Kis: 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively).		Others
T71163	Pimasertib HCl
	Pimasertib HCl is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the acti...
T21332	U0126	U 0126,U-0126	Mitophagy , MEK , Autophagy
	U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhibits autophagy and mitophagy.		Mitophagy , MEK , Autophagy
T14928	Agerafenib hydrochloride	RXDX-105 hydrochloride,CEP-32496 (hydrochloride)	c-RET , c-Kit
	Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).		c-RET , c-Kit