Powder: -20°C for 3 years | In solvent: -80°C for 1 year
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhibits autophagy and mitophagy.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 195.00 | |
5 mg | Inquiry | $ 437.00 | |
10 mg | Inquiry | $ 655.00 | |
25 mg | Inquiry | $ 1,178.00 | |
50 mg | Inquiry | $ 1,768.00 | |
100 mg | Inquiry | $ 2,652.00 | |
200 mg | Inquiry | $ 3,978.00 |
Description | U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhibits autophagy and mitophagy. |
Targets&IC50 | MEK2:60 nM (IC50), MEK1:70 nM (IC50) |
In vitro | Rat hepatocarcinoma cells (FAO) stimulated by fetal calf serum (FCS) exhibits a significant proportion in S phase (32.62%) whereas U0126 strongly decreases the proportion of cells in S phase (9.92%) and increases the proportion of cells in G0-G1 phase and to a lesser extent in G2/M[1]. U0126 efficiently reduces progeny virus titers of all tested strains in A549 cells. While nM concentrations of U0126 are efficient to reduce H1N1v and H5N1 (MB1), μM concentrations of U0126 are required to reduce the virus titer of H5N1 (GSB) and H7N7. The EC50 values for U0126-EtOH against H1N1v are 1.2 μM in A549 cells and 74.7 μM in MDCKII cells[2]. |
In vivo | In mice, U0126-EtOH (U0126; i.p., 10.5 mg/kg) inhibits tumor growth with a 60-70% reduction 9 days after injection and thereafter[1]. After treatment with U0126-EtOH(U0126; i.p., 30 mg/kg), the vasoconstriction to S6c is markedly reduced in rats[3]. |
Synonyms | U 0126, U-0126 |
Molecular Weight | 832.97 |
Formula | C43H48N10O6S |
CAS No. | 109511-58-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
H2O: Soluble
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
U0126 109511-58-2 Autophagy MAPK Mitophagy MEK MAP2K inhibit Inhibitor U 0126 Mitochondrial Autophagy U-0126 Influenza Virus MAPKK Mitogen-activated protein kinase kinase inhibitor