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Search Results for " lrp6 "

Targets

2

Compounds

4

Natural Products

10

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T11571 HLY78 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Wnt/beta-catenin
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.
T5342 IWP-O1 Wnt/beta-catenin , Porcupine
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
Cat No. Product Name Synonyms Targets
T0906 Salinomycin Procoxacin Wnt/beta-catenin , Antibacterial
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, specifically inhibits the growth of gram-positive bacteria. It acts as a potent inhibitor of Wnt/β-catenin signaling, blocking Wnt-induced LRP6 phosph...
TN1103 Diphyllin ATPase , Proton pump , Influenza Virus , HIV Protease
Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.
TL0008 Gigantol Wnt/beta-catenin , Glucosidase
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...
TQ0215 Salinomycin sodium salt Sodium salinomycin,Salinomycin sodium Apoptosis , Wnt/beta-catenin , Antibacterial , Antibiotic , Autophagy
Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00744 LRP-6 Protein, Human, Recombinant (mFc) Human HEK293 Cells
Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte ...
TMPY-02115 R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His) Human HEK293 Cells
R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in devel...
TMPH-03392 5T4/TPBG Protein, Rat, Recombinant (His & SUMO) Rat E. coli
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli ex...
TMPH-02436 5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc) Cynomolgus E. coli
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc) is expresse...
TMPH-02437 5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc) Cynomolgus HEK293 Cells
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc) is expressed in HEK2...
TMPH-01274 ZNRF3 Protein, Human, Recombinant (His & SUMO) Human E. coli
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both can...
TMPH-01275 ZNRF3 Protein, Human, Recombinant (His) Human HEK293 Cells
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both can...
TMPH-01611 LGR6 Protein, Human, Recombinant (His) Human E. coli
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with pho...
TMPH-01260 AMFR Protein, Human, Recombinant (hFc) Human HEK293 Cells
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01259 AMFR Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
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