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JNJ 303

Catalog No. T7653 CAS 878489-28-2

JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).

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JNJ 303, CAS 878489-28-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
2 mg	In stock	$ 59.00
5 mg	In stock	$ 91.00
10 mg	In stock	$ 150.00
25 mg	In stock	$ 343.00
50 mg	In stock	$ 497.00
100 mg	In stock	$ 742.00
1 mL * 10 mM (in DMSO)	In stock	$ 93.00

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Purity: 98.33%

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Description	JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
Targets&IC50	IKs:64 nM
In vitro	Optical mapping was used to measure action potential durations (APDs) in the presence of the IKs blocker JNJ-303 and the IKr blocker E-4031.?JNJ-303 alone did not increase APD.?However, under isoprenaline (ISO), both the application of JNJ-303 and additional E-4031 significantly increased APD.?With JNJ-303, ISO decreased APD significantly more in the epicardium as compared to the endocardium, with subsequent application E-4031 increasing mid- and endocardial APD80 more significantly than in the epicardium.?We found that β-AR stimulation significantly augmented the effect of IKs blocker JNJ-303, in contrast to the reduced effect of IKr blocker E-4031[1].

Molecular Weight	440.98
Formula	C21H29ClN2O4S
CAS No.	878489-28-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (24.94 mM)

References and Literature

1. Kang C , Badiceanu A , Brennan J A , et al. β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle[J]. Scientific Reports, 2017, 7(1):15922. 2. Emily R Pfeiffer-Kaushik , Godfrey L Smith , Beibei Cai, et al.Electrophysiological Characterization of Drug Response in hSC-derived Cardiomyocytes Using Voltage-Sensitive Optical Platforms.J Pharmacol Toxicol Methods, 99, 106612 Sep-Oct 2019

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Bioactive Compound Library Potassium Channel Blocker Library Ion Channel Inhibitor Library

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Keywords

JNJ 303 878489-28-2 Membrane transporter/Ion channel Potassium Channel JNJ-303 inhibit JNJ303 Inhibitor KcsA inhibitor

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