il-18 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9352	Hydrocotarnine		Others
	hydrocotarnine is an inhibitor of Cbl.		Others
T36347	Ac-YVAD-CMK	Caspase-1 Inhibitor II,Ac-Tyr-Val-Ala-Asp-chloromethylketone,Ac-Tyr-Val-Ala-Asp-CMK	IL Receptor , Caspase , Immunology/Inflammation related , Pyroptosis
	Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
T15622	JNJ-54175446	JNJ-5446	P2X Receptor
	JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression.		P2X Receptor
T37280	PE(18:1(9Z)/0:0)		Endogenous Metabolite
	PE(18:1(9Z)/0:0) is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine. PE(18:1(9Z)/0:0) induces transient increases in intracellular calcium in PC12 rat neuronal cells in a ...		Endogenous Metabolite
T6090	Belnacasan	VX-765	Caspase
	Belnacasan (VX-765) is an orally active IL-converting enzyme/caspase-1 inhibitor.		Caspase
TP2008L	Lyn peptide inhibitor acetate	Lyn peptide inhibitor acetate(222018-18-0 free base)	IL Receptor
	Lyn peptide inhibitor acetate is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the bind...		IL Receptor
T16570	Pralnacasan	VX-740,HMR 3480	Others
	Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan is an effective, non-peptide, and orally active interleukin-1β converting enzyme inhibitor (Ki: 1.4 nM). Pralnacasan has the potential ...		Others
T70905	TLR9-IN-18
	TLR9-IN-18 is a potent and selective TLR9 antagonist. TLR9-IN-18 suppresses the production of the proinflammatory cytokine IL-6 in a CpG-induced mouse model.
T7009	Soyacerebroside II		IL Receptor , Calcium Channel
	Soyacerebroside II exhibits ionophoretic activity for Ca2+ ion. Soyacerebrosides I and II have modulating the cellular immune response effects, they show obvious inhibitory activity on IL-18 secretion in human peripheral...		IL Receptor , Calcium Channel
T76938	Camoteskimab
	Camoteskimab (AVTX-007), a fully human, high-affinity anti-IL-18 monoclonal antibody, holds promise for research into autoinflammatory diseases, such as adult-onset Still’s disease (AOSD) [1].
T10447	BAA473		Others
	BAA473 is a bile acid analog that is a potent activator of the pyrin inflammasome. BAA473 can induce secretion of interleukin-18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial c...		Others
T81668	NLRP3 agonist 1		NOD-like Receptor (NLR)
	NLRP3 agonist 1 (compound 23) serves as a potent, orally active agent that activates Caspase-1 enzyme, leading to the cleavage of proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms [1].		NOD-like Receptor (NLR)
T38838	QS-21	Stimulon,QS-21
	QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, Q...
T78822	JT002		NOD-like Receptor (NLR)
	JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18) and pyroptosis, as well as inhibits the formation of the NLR...		NOD-like Receptor (NLR)
T81579	P2X7 receptor antagonist-4
	Compound 14a (P2X7 receptor antagonist-4) is a P2X7R antagonist with IC50 values of 64.7 nM in humans and 10.1 nM in mice. It inhibits the activation of the NLRP3 inflammasome, which subsequently reduces the expression o...
T68225	Fc 11a-2
	Fc 11a-2, a benzimidazole compound, functions as an orally active, potent inhibitor of the NLRP3 inflammasome. It effectively hinders the NLRP3 inflammasome formation by blocking caspase-1 activation and consequently the...
T61621	IMMH001
	IMMH001, also known as SYL930, is an orally active compound that exhibits potent selectivity as an agonist for the S1P1 receptor, which is the sphingosine-1-phosphate receptor 1. This compound effectively reduces the lev...
T37458	C18 Phytoceramide (t18:0/18:0)
	C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. cerevisiae, wheat grains, and the stratum corneum layer of mammalian epidermis. Cer(t18:0/18:0) is composed of a phytosphingosine b...
T74908	ODN 2336
	ODN 2336, an A-Class CpG oligodeoxynucleotide (ODN), serves as a potent TLR9 agonist. It effectively induces IFN-α production and up-regulates IP-10 and IL-18 mRNA expression, leveraging its role as a vaccine adjuvant [1...
T36320	C6 L-threo Ceramide (d18:1/6:0)	C6 L-threo Ceramide (d18:1/6:0)
	C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlik...