Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression. |
Targets&IC50 | P2X7 receptor (rat):8.81(pic50), P2X7 receptor (human):(pic50)8.46 , P2X7 receptor (human):8.46 (pIC50), P2X7 receptor (rat):8.81 (pIC50) |
In vitro | JNJ-54175446 is a selective purinergic P2X7 receptor (P2X7R) antagonist that attenuates the release of IL-1β/IL-18 from microglial cells[1]. |
In vivo | JNJ-54175446 (30 mg/kg, intraperitoneal) administered once daily significantly reduces spontaneous recurrent seizures in mice, persisting for several days after the end of treatment[1]. |
Synonyms | JNJ-5446 |
Molecular Weight | 440.78 |
Formula | C18H13ClF4N6O |
CAS No. | 1627902-21-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (113.44 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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JNJ-54175446 1627902-21-9 Membrane transporter/Ion channel Neuroscience P2X Receptor JNJ-5446 JNJ 54175446 JNJ54175446 inhibitor inhibit