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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T15545 | ICA-27243 | Potassium Channel | |
ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects. | |||
T26324 | VU0071063 | VU 0071063,VU-0071063 | Potassium Channel |
VU0071063 is a Kir6.2/SUR1 activator. | |||
T2535 | Ivabradine hydrochloride | S 16257-2,Ivabradine HCl | Adrenergic Receptor |
Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gat... | |||
T7516 | ZD7288 | ICI D7288 | HCN Channel |
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity. | |||
T21478 | Cromakalim | BRL-34915,BRL 34915,(±)-Cromakalim,BRL34915 | |
Cromakalim, a potassium channel-opening vasodilator, acts on ATP-sensitive potassium channels and so causes membrane hyperpolarization, it can be used to treat hypertension as it will relax vascular smooth muscle to lowe... | |||
T60400 | LDCA | Apoptosis , Dehydrogenase | |
LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis. ... | |||
T24799 | SKA-111 | SKA 111,SKA111 | Potassium Channel |
SKA-111 is a selective calcium-activated potassium phannel (potassium phannel ) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.SKA-111 binds to the interface between the CaM N-valve... | |||
T13387L | Zatebradine hydrochloride | UL-FS-49CL,UL-FS-49 | Others , HCN Channel |
Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochl... | |||
T1240 | Flumazenil | Ro 15-1788 | GABA Receptor |
Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel openi... | |||
T13387 | Zatebradine | UL-FS-49 free base,UL-FS-49CL free base | Dopamine Receptor |
Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 µM). | |||
T37748 | Ivermectin B1b | ||
Ivermectin B1b is the minor component . It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening ... | |||
T73976 | Ivabradine impurity 2 | ||
Ivabradine Impurity 2, an impurity of Ivabradine, is a compound known for its oral bioavailability and mechanism as a blocker of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels [1]. | |||
T37160 | 8-Demethyl Ivabradine | ||
8-Demethyl Ivabradine is a metabolite derived from Ivabradine, an orally bioavailable cyclic nucleotide-gated (HCN) channel blocker with hyperpolarization-activated properties[1]. | |||
T83960 | VU 0546110 | ||
VU 0546110, a selective inhibitor of the sperm-specific potassium channel SLO3 (IC50= 64 μM), demonstrates 40-fold selectivity over SLO1. It effectively blocks both heterologous SLO3 currents and endogenous K+ currents, ... | |||
T81502 | Pezadeftide | Antibiotic | |
Pezadeftide, a potent antifungal peptide, readily penetrates fungal cells, eliciting an immediate mitochondrial response that leads to hyperpolarization of the mitochondrial membrane [1]. | |||
T73975 | Ivabradine impurity 1 | ||
Ivabradine Impurity 1, identified as an impurity of Ivabradine, is an orally bioavailable compound that functions as a blocker of the hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel [1]. | |||
T63014 | Ivabradine | ||
Ivabradine is a potent, orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits pacemaker current (If). ivabradine decreases heart rate in a dose-dependent manner and does no... | |||
TP1972 | OD1 | ||
Potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 μM). Inhibits fast inac... | |||
T82683 | Connexin mimetic peptide 40GAP27 | ||
Connexin mimetic peptide 40GAP27, corresponding to the GAP27 domain of the second extracellular loop of the dominant vascular connexin (Cx40), designated as 40Gap27, is a biologically active peptide utilized to study the... | |||
T82684 | Connexin mimetic peptide 40,37GAP26 | ||
Connexin mimetic peptide 40,37GAP26, a biologically active peptide, matches the GAP26 domain of the extracellular loop of major vascular connexins Cx37 and Cx40, referred to as 37,40Gap26 based on Cx homology. It has bee... |