Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 88.00 |
Description | Zatebradine is a potent hyperpolarization-activated cyclic nucleotide-gated (HCN) channels inhibitor(IC50 of 1.96 μM). |
Targets&IC50 | HCN:1.96 µM |
In vitro | The use-dependent blockade by Zatebradine of the cardiac pacemaker current from rabbit sino-atrial node cells(Kd of 480 nM)[2]. |
In vivo | In male C57/Bl6-mice, Zatebradine (0-20 mg/kg; intraperitoneal injection; for 30 minutes) reduces the heart rate dose-dependently from 600 to 200 bpm with ED50 value of 1.8 mg/kg and induces increasing arrhythmia[1]. |
Synonyms | UL-FS-49 free base, UL-FS-49CL free base |
Molecular Weight | 456.57 |
Formula | C26H36N2O5 |
CAS No. | 85175-67-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (109.51 mM)
You can also refer to dose conversion for different animals. More
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Zatebradine 85175-67-3 GPCR/G Protein Neuroscience Dopamine Receptor UL-FS-49 free base UL-FS-49CL free base UL-FS-49CL UL-FS-49 inhibitor inhibit