6
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0676 | Hydroxyurea | Hydroxycarbamide,nsc32065,nci-c04831 | Apoptosis , HIV Protease , DNA/RNA Synthesis , Autophagy |
Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. | |||
T10208 | A-69412 | N-1-(Fur-3-ylethyl)-N-hydroxyurea | Lipoxygenase |
A-69412 (N-1-(Fur-3-ylethyl)-N-hydroxyurea) is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other inflammatory and allergic... | |||
T6612 | NU6027 | ATM/ATR , DNA-PK , CDK | |
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors. | |||
T0477 | Zileuton | Abbott 64077,A 64077 | Ferroptosis , Lipoxygenase , COX |
Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; ca... | |||
T4570 | Pipobroman | Vercyte,A-8103,Amedel | Others , DNA Alkylator/Crosslinker |
Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit... | |||
T68398 | MI-223 | ||
MI-223 is an inhibitor of Mcl-1-stimulated homologous recombination (HR) DNA repair, which leads to sensitization of cancer cells to hydroxyurea- or olaparib-induced DNA replication stress. |