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Search Results for " hydroxyurea "

6

Compounds

Cat No. Product Name Synonyms Targets
T0676 Hydroxyurea Hydroxycarbamide,nsc32065,nci-c04831 Apoptosis , HIV Protease , DNA/RNA Synthesis , Autophagy
Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
T10208 A-69412 N-1-(Fur-3-ylethyl)-N-hydroxyurea Lipoxygenase
A-69412 (N-1-(Fur-3-ylethyl)-N-hydroxyurea) is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other inflammatory and allergic...
T6612 NU6027 ATM/ATR , DNA-PK , CDK
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.
T0477 Zileuton Abbott 64077,A 64077 Ferroptosis , Lipoxygenase , COX
Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; ca...
T4570 Pipobroman Vercyte,A-8103,Amedel Others , DNA Alkylator/Crosslinker
Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit...
T68398 MI-223
MI-223 is an inhibitor of Mcl-1-stimulated homologous recombination (HR) DNA repair, which leads to sensitization of cancer cells to hydroxyurea- or olaparib-induced DNA replication stress.
TargetMol