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Hydroxyurea

Catalog No. T0676 CAS 127-07-1

Synonyms: Hydroxycarbamide, nsc32065, nci-c04831

Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.

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Hydroxyurea, CAS 127-07-1

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500 mg	In stock	$ 45.00
1 g	In stock	$ 53.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.92%

Purity: 99.87%

Purity: 99.85%

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Description	Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
In vitro	hydroxyurea can inhibit HIV-1 replication. In vitro experiments have shown that the 90% inhibitory concentration (IC90) of hydroxyurea for laboratory strains of HIV-1 in activated PBMC is 0.4 mM. Hydroxyurea was also found to be synergistic with the nucleoside reverse transcriptase inhibitor didanosine and to inhibit HIV-1 replication in activated PBMC; this inhibition may be due to a reduction in deoxynucleoside triphosphate pool sizes. Hydroxyurea has been shown to sensitize didanosine-resistant mutants[1][2].hydroxyurea has demonstrated activity in the treatment of sickle cell anemia by increasing the production of fetal hemoglobin, which reduces hemolysis in patients with this disease. Hydroxyurea exerts its cytostatic effect through inhibition of ribonucleotide reductase—the rate-limiting enzyme responsible for the conversion of ribonucleotides to deoxyribonucleotides, which are essential for DNA synthesis. As a result, cellular division is arrested in the S phase[1].
In vivo	Hydroxyurea treatment consistently decreases white blood cell (WBC) and absolute neutrophil count (ANC), yet does not enhance anemia over a 17-week period. At a dosage of 50 mg/kg, hydroxyurea effectively lowers WBC and ANC without ameliorating anemia in comparison to vehicle-treated sickle cell mice [5].
Cell Research	Erythroid cells obtained from peripheral blood of the same patients(Thirteen β-Thal/HbE patients are treated with hydroxyurea orally for 2 years at a starting dose of 5 mg/kg/day for 5 days/week with escalation to a maximum of 10 mg/kg/day) 1 year after they had stopped hydroxyurea treatment are treated with hydroxyurea in vitro.Treatment of cells performs in primary culture with 30 μM hydroxyurea for 96 hours.(Only for Reference)

Synonyms	Hydroxycarbamide, nsc32065, nci-c04831
Molecular Weight	76.05
Formula	CH4N2O2
CAS No.	127-07-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (657.38 mM)

H2O: 55 mg/mL (723.11 mM)

References and Literature

1. Lori F, et al. Clin Infect Dis. 2000, 30 Suppl 2:S193-7. 2. Zala C, et al. Clin Infect Dis. 2000, Suppl 2:S143-50. 3. Watanapokasin Y, et al. Exp Hematol. 2005, 33(12):1486-92. 4. Boucher PD, et al. Gene Ther. 2002, 9(15):1023-30. 5. Lebensburger JD, et al. Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Haematologica. 2010 Sep;95(9):1599-603.

Citations

1. Zhu H, Rao Z, Yuan S, et al. One therapeutic approach for triple-negative breast cancer: Checkpoint kinase 1 inhibitor AZD7762 combination with neoadjuvant carboplatin. European Journal of Pharmacology. 2021: 174366.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Toxic Compound Library FDA-Approved Drug Library Drug-induced Liver Injury (DILI) Compound Library Anti-Lung Cancer Compound Library

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Keywords

Hydroxyurea 127-07-1 Apoptosis Autophagy Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Proteases/Proteasome DNA/RNA Synthesis HIV Protease Hydroxycarbamide Inhibitor Human immunodeficiency virus inhibit HIV nsc32065 nci-c04831 inhibitor

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