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Zileuton

Catalog No. T0477 CAS 111406-87-2

Synonyms: A 64077, Abbott 64077

Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Zileuton, CAS 111406-87-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	A 64077, Abbott 64077
Molecular Weight	236.29
Formula	C11H12N2O2S
CAS No.	111406-87-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 23.6 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Rossi A1, et al. Br J Pharmacol, 2010, 161(3), 555-570. 2. Bertrán X, et al.Gut. 1996 Jun;38(6):899-904. 3. Genovese T, et al. Br J Pharmacol, 2008, 153(3), 568-582. 4. Patel NS, et al. Mol Pharmacol, 2004, 66(2), 220-227. 5. Rao NL, et al. J Pharmacol Exp Ther, 2007, 321(3), 1154-1160. 6. Gounaris E, et al. Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One. 2015 Mar 6;10(3):e0121402 7. Abueid L, et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10 8. Liu L, Zhang P, Zhang Z, et al. 5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats[J]. Aging (Albany NY). 2021, 13(8): 11752.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Lipid Metabolism Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.