hmgb1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T82189	HMGB1-IN-2
	HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At a concentration of 30 μM, HMGB1-IN-2 reduces...
T78056	HMGB1-IN-1
	HMGB1-IN-1 (compound 6) exhibits potent inhibition of NO production in RAW264.7 cells, with an IC50 of 15.9 ± 0.6 μM, and effectively disrupts the HMGB1/NF-κB/NLRP3 signaling pathway. This compound demonstrates promising...
T4074	GSK-872	GSK872,GSK'872,GSK2399872A	RIP kinase
	GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).		RIP kinase
T24167	Inflachromene	ICM	Others
	Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial...		Others
T9948	NecroX-7	LC-280126,LC28-0126,LC28 0126	NADPH-oxidase
	NecroX-7 (LC-280126) is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing ...		NADPH-oxidase
T2741	Glycyrrhizic acid	Glycyrrhizin	Virus Protease , Dehydrogenase , MAO
	Glycyrrhizic acid (Glycyrrhizin) is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.		Virus Protease , Dehydrogenase , MAO
TN6774	Emodin 6-O-β-D-glucoside	Glucoemodin	Others
	Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside ...		Others
T6S0721	Orientin	Lutexin,Luteolin-8-glucoside	Others
	1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier int...		Others
T5S1632	Barlerin	8-O-Acetylshanzhiside methyl ester,ND01	VEGFR , TNF , NF-κB , Akt , Caspase
	Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...		VEGFR , TNF , NF-κB , Akt , Caspase
T31411	DHA-37	DHA 37
	DHA-37 is an inducer of autophagic cell death through upregulation of HMGB1 in A549 cells.
T63660	Anti-inflammatory agent 19
	Anti-inflammatory agent 19 inhibits NO (IC50: 36.00 μM). anti-inflammatory agent 19 exhibits an inhibitory effect on HMGB1-induced late inflammatory responses. anti-inflammatory agent 19 can be used to study late inflamm...
T63473	Anti-inflammatory agent 18
	Anti-inflammatory agent 18 inhibits NO activity (IC50: 15.94 μM) and has an inhibitory effect on the late inflammatory response induced by HMGB1 and can be used to study late inflammatory diseases such as coronavirus dis...