hdl — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T24134	HDL376	SDZ-HDL376,SDZHDL376,HDL 376,SDZ HDL376,HDL-376	Others
	HDL376 (SDZ HDL376) is a scavenger receptor BI inhibitor.		Others
T7832	Ibrolipim	NO-1886	LPL Receptor
	Ibrolipim (NO-1886) attenuates high glucose-induced endothelial dysfunction in cultured human umbilical vein endothelial cells via PI3K/Akt pathway.		LPL Receptor
T6048	Dalcetrapib	JTT-705,RO4607381	CETP
	Dalcetrapib (RO4607381), a rhCETP inhibitor (IC50=0.2 μM), increases the plasma HDL cholesterol.		CETP
T2499	Torcetrapib	CP-529414	CETP
	Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to exces...		CETP
T14667	BLT-1		Others , HCV Protease
	BLT-1 is a scavenger receptor BI (SR-BI)inhibitor.		Others , HCV Protease
T15549	Icosabutate		Others
	Icosabutate is a structurally engineered and orally active ω-3 polyunsaturated fatty acid. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persist...		Others
T1928	Anacetrapib	MK-0859	CETP
	Anacetrapib (MK-0859) (MK0859) is an effective, specific, reversible rhCETP and mutant CETP(C13S) inhibitor (IC50: 7.9 nM and 11.8 nM). Anacetrapib reduces the transfer of cholesteryl ester from HDL to LDL and/or VLDL th...		CETP
T3427	Polydatin	Piceid,Polydotin Peceid	Apoptosis , Mitophagy , NF-κB , Autophagy
	Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...		Apoptosis , Mitophagy , NF-κB , Autophagy
T15821	LY518674	LY-674	PPAR
	LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα).		PPAR
T6262	Evacetrapib	LY2484595	CETP
	Evacetrapib (LY2484595) (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. Phase 3.		CETP
T3771	Methyl protodioscin	Smilax saponin B,NSC-698790	Apoptosis
	Methyl protodioscin (Smilax saponin B) potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl protodioscin induced apoptotic process in h...		Apoptosis
T1415	Gemfibrozil	CI-719,Jezil,Decrelip,Lopid	P450 , Adrenergic Receptor , PPAR
	Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi...		P450 , Adrenergic Receptor , PPAR
T30917	CI 924	EINECS 279-174-7,CI-924,CI924
	CI 924 is a lipid-lowering drug. CI 924 increased anti-atherosclerotic HDL and decreased VLDL at 600 mg/day.
T30588	Brl 26314	Brl-26314,Brl26314
	Brl 26314 can elevate HDL-cholesterol in rats.
T10771	CETP-IN-3		Others
	CETP-IN-3 is an inhibitor of the plasma glycoprotein cholesterol ester transfer protein (CETP), elevating HDL-C through inhibition of CETP.		Others
T69408	GW590735 sodium
	GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased...
T68505	Obicetrapib sodium
	Obicetrapib sodium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial ...
T68504	Obicetrapib calcium
	Obicetrapib calcium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial...
T38908	MK-8262
	MK-8262, an orally active and potent cholesteryl ester transfer protein (CETP) inhibitor (IC 50 = 53 nM, log D = 5.3), is a bistrifluoromethyl analogue that shows promise in research related to high-density lipoprotein (...
T11386	Gemcabene calcium	PD-72953 calcium	Others
	Gemcabene calcium , a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) andexerting anti-inflammator...		Others