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HDL376

Catalog No. T24134 CAS 147751-31-3

Synonyms: SDZ-HDL376, SDZHDL376, HDL 376, SDZ HDL376, HDL-376

HDL376 (SDZ HDL376) is a scavenger receptor BI inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

HDL376, CAS 147751-31-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 148.00
5 mg	In stock	$ 336.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 793.00
50 mg	In stock	$ 1,130.00
100 mg	In stock	$ 1,520.00
1 mL * 10 mM (in DMSO)	In stock	$ 298.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	HDL376 (SDZ HDL376) is a scavenger receptor BI inhibitor.
In vivo	HDL376 was shown to raise HDL cholesterol in the rat (normal-fed 80 mg/kg/day), hamster (normal-fed 52 mg/kg/day, chow-fed 64 mg/kg/day), dog (normal-fed 35 mg/kg/day), rhesus monkey (12 mg/kg/day), and cynomolgus monkeymodels (12 mg/kg/day)[2].

Synonyms	SDZ-HDL376, SDZHDL376, HDL 376, SDZ HDL376, HDL-376
Molecular Weight	256.79
Formula	C12H17ClN2S
CAS No.	147751-31-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (194.7 mM)

References and Literature

1. Nieland TJ, Shaw JT, Jaipuri FA, Maliga Z, Duffner JL, Koehler AN, Krieger M. Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI. J Lipid Res. 2007 Aug;48(8):1832-45. Epub 2007 May 28. PubMed PMID: 17533223. 2. Coppola GM, Damon RE, Eskesen JB, France DS, Paterniti JR Jr. Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents. Bioorg Med Chem Lett. 2006 Jan 1;16(1):113-7. Epub 2005 Oct 10. PubMed PMID: 16216504. 3. Stevens GJ, Hitchcock K, Wang YK, Coppola GM, Versace RW, Chin JA, Shapiro M, Suwanrumpha S, Mangold BL. In vitro metabolism of N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)thiourea: species comparison and identification of a novel thiocarbamide-glutathione adduct. Chem Res Toxicol. 1997 Jul;10(7):733-41. PubMed PMID: 9250406.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HDL376 147751-31-3 Others SDZ-HDL376 SDZHDL376 SDZ HDL-376 SDZ HDL 376 HDL 376 SDZ HDL376 SDZHDL-376 SDZ-HDL 376 SDZHDL 376 HDL-376 SDZ-HDL-376 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.