Search Result

Search Results for " gp130 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9157	GP130 receptor agonist-1	N-(4-Fluorophenyl)-4-phenyl-2-thiazolami	Interleukin
	GP130 receptor agonist-1 (N-(4-Fluorophenyl)-4-phenyl-2-thiazolami) is a potent, brain-penetrant and orally active GP130 receptor agonist.		Interleukin
T2544	Bazedoxifene acetate	WAY-TES 424,TSE 424,WAY-140424	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM).		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T6404	Bazedoxifene hydrochloride	Bazedoxifene HCl,TSE-424	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T6207	SC144		Apoptosis , Interleukin
	SC144 is an orally active small-molecule gp130 inhibitor.		Apoptosis , Interleukin
T5359	RCGD423		Interleukin
	RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair.		Interleukin
T77672	JI069	WAY-354189	JAK , STAT
	JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.		JAK , STAT
T15769	LMT-28		IL Receptor
	LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2.		IL Receptor
T41260	SC144 hydrochloride
	SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation...
T72754	JAK2/STAT3-IN-1
	JAK2/STAT3-IN-1 -10a) is a potent inhibitor of GP130, exhibiting an IC50 value of 3.04 µM and demonstrating anti-tumor activity.
T19728	SPRC	S-Propargyl-cysteine
	SPRC is a novel synthetic molecule exerting antioxidant effects via elevating the generation of endogenous H2S. SPRC activates Gp130-mediated STAT3 and prevents doxorubicin-induced cardiotoxicity.
T74734	Truncated ADR58
	Truncated ADR58, derived by shortening full-length ADR58 from 71 bases to 31 bases, maintains comparable functional activity to its full-length counterpart. This compound acts as a potent and selective antagonist of huma...

Compounds

GP130 receptor agonist-1

T9157

Synonym: N-(4-Fluorophenyl)-4-phenyl-2-thiazolami

Target: Interleukin

Bazedoxifene acetate

T2544

Synonym: WAY-TES 424,TSE 424,WAY-140424

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Bazedoxifene hydrochloride

T6404

Synonym: Bazedoxifene HCl,TSE-424

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

SC144

T6207

Synonym:

Target: Apoptosis, Interleukin

Synonym: S-Propargyl-cysteine

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01076	gp130/IL6ST Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	gp130/IL6ST Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 96 kDa and the accession number is P40189-1.
TMPY-01832	gp130/IL6ST Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	gp130/IL6ST Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68 kDa and the accession number is Q00560.
TMPK-00646	gp130/IL6ST Protein, Rhesus macaque, Recombinant (His)	Rhesus	HEK293 Cells
	gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic fa...
TMPY-06745	gp130/IL6ST Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	gp130/IL6ST Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 94.11 kDa and the accession number is AAA59155.1.
TMPY-00387	gp130/IL6ST Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	gp130/IL6ST Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 94.4 kDa and the accession number is AAA59155.1.
TMPK-00412	gp130/IL6ST Protein, Human, Recombinant (His)	Human	HEK293 Cells
	gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic fa...
TMPY-06039	gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK)	Human	HEK293 Cells
	gp130/IL6ST Protein, Human, Recombinant (aa 1-618, DDDDK) is expressed in HEK293 mammalian cells. The predicted molecular weight is 68.4 kDa and the accession number is P40189-1.
TMPY-05793	gp130/IL6ST Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	gp130/IL6ST Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 93.38 kDa and the accession number is Q00560.
TMPY-01250	IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	IL-11R alpha/IL-11RA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.2 kDa and the accession number is Q64385.
TMPY-03687	gp130/IL6ST Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293 Cells
	gp130/IL6ST Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 102.6 kDa and the accession number is A0A8J8YAN3.
TMPY-03743	gp130/IL6ST Protein, Rhesus, Recombinant (His)	Rhesus	HEK293 Cells
	gp130/IL6ST Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.2 kDa and the accession number is A0A8J8YAN3.
TMPY-02148	gp130/IL6ST Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	gp130/IL6ST Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 68.2 kDa and the accession number is H9BFG4.
TMPY-01995	gp130/IL6ST Protein, Rat, Recombinant (His & mFc)	Rat	HEK293 Cells
	gp130/IL6ST Protein, Rat, Recombinant (His & mFc) is expressed in HEK293 mammalian cells with His, mFc tag. The predicted molecular weight is 94.3 kDa and the accession number is H9BFG4.
TMPH-03099	Aminopeptidase N/CD13 Protein, Pig, Recombinant (His & Myc)	Sus scrofa (Pig)	E. coli
	Aminopeptidase N/CD13 Protein, Pig, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 47.1 kDa and the accession number is P15145.
TMPK-01114	IL-31RA Protein, Human, Recombinant (aa 20-519, His)	Human	HEK293 Cells
	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex f...
TMPK-01096	IL-31RA Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex f...
TMPK-01113	IL-31RA Protein, Human, Recombinant (aa 20-519, hFc)	Human	HEK293 Cells
	Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex f...
TMPJ-01467	Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, ...
TMPK-00289	IL-6R alpha/CD126 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low af...
TMPK-00089	IL-11 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which tri...
TMPK-00356	IL-27RA/TCCR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-27Ra (also known as TCCR and WSX1) as a gene whose expression can induce the transformation of hematopoietic cells. IL-27Ra (IL-27R) is a type I cytokine receptor that functions as the ligand binding component of the ...
TMPK-00088	IL-11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which tri...
TMPJ-00086	CT-1 Protein, Human, Recombinant (His)	Human	E. coli
	Cardiotrophin-1, also known as CT-1 and CTF1, is a member of the IL-6 superfamily. It is a sreted cytokine that is expressed in heart, skeletal muscle, prostate and ovary, and to lower levels in lung, kidney, pancreas, t...
TMPJ-00081	CNTF Protein, Human, Recombinant	Human	E. coli
	Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species ...
TMPJ-01199	BTN2A1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Butyrophilin 2A1 (BTN2A1) is an approximately widely expressed and variably glycosylated type I transmembrane glycoprotein. Mature human Butyrophilin 2A1 consisits of a 220 amino acid (aa) extracellular domain with two i...
TMPY-02843	GPX7 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	GPX7 gene contains 3 distinct gt-ag introns. Transcription produces 4 different mRNAs, 3 alternatively spliced variants, and 1 unspliced form. There are 5 validated alternative polyadenylation sites. The mRNAs appear to ...
TMPJ-00047	IL-31 Protein, Human, Recombinant	Human	E. coli
	Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes...
TMPH-01503	Humanin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...
TMPH-01502	Humanin Protein, Human, Recombinant (GST)	Human	E. coli
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e...