Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 247.00 | |
50 mg | In stock | $ 389.00 | |
100 mg | In stock | $ 569.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | LMT-28 is an inhibitor of IL-6 and selectively inhibits IL-6-induced phosphorylation of gp130, STAT3, and JAK2. |
In vitro | LMT-28 (1-10000 nM) inhibits IL-6-induced cell proliferation(IC50 = 7.5 μM)[1]. |
In vivo | In male DBA/1J collagen-induced arthritis mice, LMT-28 (0-0.5 mg/kg) reduces the serum levels of cartilage oligomeric matrix protein, serum amyloid P and anti-CII IgG by 50%, 55%, and 62%[1]. |
Molecular Weight | 311.42 |
Formula | C17H29NO4 |
CAS No. | 1239600-18-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (289.0 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LMT-28 1239600-18-0 Immunology/Inflammation IL Receptor LMT28 LMT 28 inhibitor inhibit