gm-csf — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3133	YM-90709	YM90709,YM 90709	IL Receptor , Interleukin
	YM-90709 is a new-type antagonist inhibiting the binding of interleukin-5 to the interleukin-5 receptor.		IL Receptor , Interleukin
T3185	R112	(E)-Elafibranor	Syk
	R112 ((E)-Elafibranor) is an ATP-competitive inhibitor of Syk kinase.		Syk
T80585	Anti-Mouse GM-CSF Antibody (MP1-22E9)		c-Fms
	Anti-Mouse GM-CSF Antibody is a rat-derived IgG2a isotype inhibitor that targets mouse granulocyte-macrophage colony-stimulating factor (GM-CSF).		c-Fms
T0089	Cetirizine dihydrochloride	P071,UCB P071,Cetirizine DiHCl	Histamine Receptor
	Cetirizine dihydrochloride (UCB P071) is an effective second-generation histamine H1 antagonist that is potent in the therapy of allergic rhinitis, confirmed urticaria, and pollen-induced asthma. Unlike other conventiona...		Histamine Receptor
T76690	Mavrilimumab	CAM 3001	Virus Protease , CSF-1R
	Mavrilimumab (CAM 3001) is a monoclonal antibody with antiviral activity that has an affinity for the α subunit of the granulocytic-macrophage colony-stimulating factor (GM-CSF) receptor and blocks downstream intracellul...		Virus Protease , CSF-1R
T77125	Otilimab	GSK 3196165,MOR103	CSF-1R
	Otilimab (GSK 3196165) is a humanized monoclonal antibody against granulocyt-macrophage colony-stimulating factor (GM-CSF). Otilimab has anti-inflammatory activity, regulates the biological function of GM-CSF by blocking...		CSF-1R
T9840	Ataquimas		Immunology/Inflammation related
	Ataquimast inhibits IL-5 secretion along with that of TNF-a, IL-4 and GM-CSF from human cells.		Immunology/Inflammation related
T81135	Sodium caseinates
	Sodium caseinate, the predominant milk protein salt of casein, promotes the proliferation and activation of granulocytes and elevates serum concentrations of cytokines GM-CSF and G-CSF, thereby inducing murine granulopoi...
T29797	AKB-6899	AKB6899	VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
	AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which in...		VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
TP2008L	Lyn peptide inhibitor acetate	Lyn peptide inhibitor acetate(222018-18-0 free base)	IL Receptor
	Lyn peptide inhibitor acetate is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the bind...		IL Receptor
T76820	Namilumab
	Namilumab (AMG203), a human IgG1 monoclonal antibody, exhibits high affinity binding to the GM-CSF ligand, effectively neutralizing GM-CSF. It has potential application in researching rheumatoid arthritis [1].
T79149	Magmas-IN-1		Others
	Magmas-IN-1 (compound 9), a small molecule Magmas inhibitor (SMMI), targets the mitochondria-associated granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling molecule and GM-CSF inducible gene in myeloid ce...		Others
T77025	Gimsilumab
	Gimsilumab (MORAb-022), a humanized anti-GM-CSF monoclonal antibody, shows promise in the research of COVID-19 and rheumatoid arthritis (RA) [1] [2].
T77116	Plonmarlimab
	Plonmarlimab (TJ003234), an anti-GM-CSF monoclonal antibody, is utilized in researching rheumatoid arthritis and COVID-19 [1] [2].
T76751	Lenzilumab
	Lenzilumab (KB 003) is a humanized monoclonal antibody designed to target CSF2/GM-CSF, with applications in COVID-19 and studies on chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) [1] [...
T73659	HLF1-11
	HLF1-11, derived from human lactoferrin, serves as a broad-spectrum antimicrobial agent. It not only inhibits human MPO (myeloperoxidase) activity but also influences GM-CSF (granulocyte-macrophage colony-stimulating fac...
T74971	Diamino lipid DAL4
	Diamino lipid DAL4 is novel lipid nanoparticles (LNPs) encapsulated with mRNAs encoding cytokines including IL-12 , IL-27 and GM-CSF . Diamino lipid DAL4 delivers mRNA to tumor cells to exert anti-tumor activity [1] .
T82938	ATUX-1215
	ATUX-1215, a protein phosphatase 2A (PP2A) activator, diminishes the phosphorylation of ERK, p38, JNK, and Akt, as well as decreases the secretion of IL-12p70, GM-CSF, and IL1α in BLM-treated animals, potentially deceler...
TP2008	Lyn peptide inhibitor
	Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinoph...
T80959	Trabikibart	CSL311
	Trabikibart (CSL311), a βc-specific, fully human monoclonal antibody, specifically binds to the cytokine-binding epitope of the human βc receptor with picomolar affinity. It potently inhibits the collective impact of IL-...