gcase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4280	Gcase activator 1	LTI-291,LTI 291,LTI291	Glucosidase
	Gcase activator 1 (LTI-291) is a glucocerebrosidase (Gcase) activator.		Glucosidase
T82330	GCase modulator-1		Glucosidase
	GCase Modulator-1 (Compound 9g), a quinazoline derivative, functions as a glucosidase modulator with an AC50 value of 2.23 µM [1].		Glucosidase
T78573	Glucocerebrosidase	GCase,Glucosylceramidase	Endogenous Metabolite
	Glucocerebrosidase (Glucosylceramidase; GBA), a lysosomal enzyme, catalyzes the hydrolysis of the β-glucosidic linkage in glucocerebroside (GC) to yield glucose and ceramide [1].		Endogenous Metabolite
T8986	ML198		Glucokinase
	ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecule treatment for patients suffering from Gaucher disease.		Glucokinase
T0920	Ambroxol	Ambroxolum,NA-872	P450 , Autophagy
	Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a muco...		P450 , Autophagy
T6234	Ambroxol hydrochloride	Mucosolvan,Mucoangin,Ambroxol HCl	Sodium Channel , Autophagy
	Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.		Sodium Channel , Autophagy
T75407	Endoglycoceramidase I (EGCase I)
	Endoglycoceramidase I (EGCase I), a glycosidase frequently utilized in biochemical studies, catalyzes a transglycosylation reaction. This process involves transferring the sugar moiety of GSLs to the primary hydroxyl gro...
T75406	Endoglycoceramidase II (EGCase II)
	Endoglycoceramidase II (EGCase II), an endo-β-glucosidase, catalyzes the hydrolysis of the β-glycosidic linkage between oligosaccharides and ceramides in glycosphingolipids, releasing the complete glycan from ceramide [1...
T8989	NCGC 607	NCGC607	Others
	NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).		Others
T8990	ML266		Glucokinase
	ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 µM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function. This compo...		Glucokinase
TQ0300	Conduritol B epoxide		Glucosidase
	Conduritol B epoxide is an irreversible inhibitor of β-glucosidase (GCase).		Glucosidase
T39518	PFB-FDGlu		Others
	PFB-FDGlu is a lysosomal Glucocerebrosidase (GCase) substrate with cell-permeable specificity that is cleaved to produce fluorescein.PFB-FDGlu is often used in conjunction with a flow cytometer to measure GCase activity ...		Others
T35626	AMP-Deoxynojirimycin	AMP-DNM	Transferase , Glucosidase
	AMP-Deoxynojirimycin (AMP-DNM) is a potent inhibitor of ceramide glucosyltransferase and GCase 2.AMP-Deoxynojirimycin is a potent inhibitor of GlcCer biosynthesis and is used in the study of Parkinson's and diabetes.		Transferase , Glucosidase
T37571	4-Methylumbelliferyl-β-D-Glucopyranoside	MU-GLU,4-MUG,4-MU-GLU,4-MU-β-Gluc	Others
	4-Methylumbelliferyl-β-D-Glucopyranoside (4-MU-GLU) is used in the GCase activity assay based on the catalytic hydrolysis of 4-methylumbelliferyl β-D-glucopyranoside that releases the highly fluorescent 4-methylumbellife...		Others
T71476	Afegostat TFA
	Afegostat, aslo known as Isofagomine, and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a ...
T19182	Afegostat D-Tartrate	Isofagomine D-Tartrate,D-Isofagomine D-Tartrate	Others
	Afegostat D-Tartrate is a pharmacological chaperone that specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum with high affinity.		Others
T60353	Glucocerebrosidase-IN-1
	Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC 50 of 29.3 μM and a K i of 18.5 μM. Due to GCase involvement in pathological disorders consequent to enzym...
T23653	Afegostat HCl	Afegostat,AT-2101,Afegostat hydrochloride,AT2101
	Afegostat is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. Afegostat inhibits GCase with K(i) ~30 nM for wild-type and mutant enzymes. Afegostat was an experimental drug fo...
T19181	Afegostat	D-Isofagomine,Isofagomine	Others
	Afegostat is a pharmacological chaperone that specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum with high affinity.		Others
T78671	Glucocerebrosidase-IN-1 hydrochloride		Glucosidase
	Glucocerebrosidase-IN-1 (compound 11a) hydrochloride is a potent, selective GCase (glucocerebrosidase) inhibitor with IC50 and Ki values of 29.3 μM and 18.5 μM, respectively. It is utilized in the research of Gaucher dis...		Glucosidase