Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Afegostat D-Tartrate is a pharmacological chaperone that specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum with high affinity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 198.00 | |
5 mg | 35 days | $ 494.00 | |
10 mg | 35 days | $ 891.00 |
Description | Afegostat D-Tartrate is a pharmacological chaperone that specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum with high affinity. |
In vivo | Afegostat D-Tartrate enhances GCase activity in the brain, liver, and spleen. When administered orally at a dosage of 100 mg/kg to Thy1-aSyn mice for four months, Afegostat notably improves motor and non-motor functions, eliminates microglial inflammatory responses in the substantia nigra, diminishes α-synuclein immunoreactivity in nigral dopaminergic neurons, and adjusts the size distribution of α-synuclein aggregates by reducing small aggregates and augmenting larger ones. |
Synonyms | Isofagomine D-Tartrate, D-Isofagomine D-Tartrate |
Molecular Weight | 297.26 |
Formula | C10H19NO9 |
CAS No. | 957230-65-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Afegostat D-Tartrate 957230-65-8 Others Afegostat DTartrate Isofagomine D-Tartrate D-Isofagomine D-Tartrate Afegostat D Tartrate inhibitor inhibit