Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 42.00 | |
5 mg | In stock | $ 139.00 | |
10 mg | In stock | $ 222.00 | |
25 mg | In stock | $ 375.00 | |
50 mg | In stock | $ 553.00 | |
100 mg | In stock | $ 789.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 179.00 |
Description | NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase). |
In vitro | NCGC607, a small-molecule noninhibitory chaperone of glucocerebrosidase identified by high-throughput screening and medicinal chemistry structure optimization.?This compound successfully chaperoned the mutant enzyme, restored glucocerebrosidase activity and protein levels, and reduced glycolipid storage in both iPSC-derived macrophages and dopaminergic neurons, indicating its potential for treating neuronopathic Gaucher disease.?In addition, NCGC607 reduced α-synuclein levels in dopaminergic neurons from the patients with parkinsonism, suggesting that noninhibitory small-molecule chaperones of glucocerebrosidase may prove useful for the treatment of Parkinson disease. |
Synonyms | NCGC607 |
Molecular Weight | 543.35 |
Formula | C24H22IN3O4 |
CAS No. | 1462267-07-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (101.22 mM)
You can also refer to dose conversion for different animals. More
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NCGC 607 1462267-07-7 Others inhibit Glucosidase Inhibitor NCGC-607 NCGC607 inhibitor