g9a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7378	BRD9539		Histone Methyltransferase
	BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM		Histone Methyltransferase
T1923	BRD4770		Histone Methyltransferase
	BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.		Histone Methyltransferase
T17204	UNC0321		Histone Methyltransferase
	UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.		Histone Methyltransferase
T2354	UNC 0631	UNC0631	Histone Methyltransferase
	UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).		Histone Methyltransferase
T17203	UNC0224		Histone Methyltransferase
	UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.		Histone Methyltransferase
TQ0232	UNC0646	UNC 0646	Histone Methyltransferase
	UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells ...		Histone Methyltransferase
T7194	CM-272		Apoptosis , DNA Methyltransferase , Histone Methyltransferase
	CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T4166	UNC0642	UNC-0642,UNC 0642	Histone Methyltransferase
	UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).		Histone Methyltransferase
T1959	BIX-01294 trihydrochloride	BIX 01294	Histone Methyltransferase , Autophagy
	BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.		Histone Methyltransferase , Autophagy
T7697	BIX-01294		Histone Methyltransferase , Autophagy
	BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).		Histone Methyltransferase , Autophagy
T28112	MS0124	MS 0124,MS-0124	Histone Methyltransferase
	MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.		Histone Methyltransferase
T10882	CPUY074020		Histone Methyltransferase
	CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.		Histone Methyltransferase
T3624	A-366	A 366,A366	Epigenetic Reader Domain , Histone Methyltransferase
	A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met...		Epigenetic Reader Domain , Histone Methyltransferase
T10840L	CM-579		DNA Methyltransferase , Histone Methyltransferase
	CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.		DNA Methyltransferase , Histone Methyltransferase
T3257	UNC0638		Influenza Virus , Histone Methyltransferase , Autophagy
	UNC0638 is an inhibitor of β-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets.		Influenza Virus , Histone Methyltransferase , Autophagy
T63140	LSD1-IN-20		Histone Demethylase
	Lsd1-in-20 is a potent dual inhibitor of LSD1/G9a with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 showed antiproliferative activity against THP-1 leukemia cells and MDA-MB-231 breast cancer cells in vitro, w...		Histone Demethylase
T63351L	MS8511 HCl	MS8511 HCl(2866408-21-9 Free base)	Histone Methyltransferase
	MS8511 HCl is a selective and potent covalent inhibitor of G9a/GLP that acts by targeting cysteine residues in the substrate binding site. MS8511 has anticancer activity and antiproliferative activity and reduces intrace...		Histone Methyltransferase
T6803	Chaetocin		Histone Methyltransferase , Antibacterial , Antibiotic
	Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.		Histone Methyltransferase , Antibacterial , Antibiotic
T67947	WDR5-0102		Histone Methyltransferase
	WDR5-0102 is a compound that inhibits the WDR5-MLL1 interface (K dis = 7 μM, K d = 4 μM), selectively reducing MLL1 HMT activity without affecting the human H3K4 methyltransferase SETD7 or other HMTs, including G9a, EHMT...		Histone Methyltransferase
T11185	EML741		Histone Methyltransferase
	EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated. EML741 is a histone lysine methyltransferase...		Histone Methyltransferase